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Regulation of murine airway responsiveness by endothelial nitric oxide synthase.
It is demonstrated that the three NOS isoforms are expressed constitutively in murine lung and that NO derived from eNOS plays a physiological role in controlling bronchial airway reactivity. Expand
Mechanisms of pulmonary edema induced by an organophosphorus compound in anesthetized dogs.
It is suggested that VX injection induces an increase in pulmonary capillary permeability which may lead to a high-permeability edema. Expand
Cardiac abnormalities in rats treated with methylphosphonothiolate.
  • P. Robineau
  • Chemistry, Medicine
  • Toxicology and applied pharmacology
  • 1 February 1987
Cardiac toxicity of methylphosphonothiolate (MPT), an organophosphorus compound, has been investigated in the rat and death rate among MPT-treated animals appeared to be in relationship with cardiac arrhythmias. Expand
In vitro and in vivo pharmacology of S 16474, a novel dual tachykinin NK1 and NK2 receptor antagonist.
It is demonstrated clearly that S 16474 is a tachykinin receptor antagonist exhibiting, in vitro and in vivo, a dual inhibitory effect on NK1 and NK2 receptors. Expand
Cardiovascular effects of SL65.0472, a 5-HT receptor antagonist.
In vivo, SL65.0472 potently antagonises vasoconstriction mediated by 5- HT(1B) and 5-HT(2A) receptors but has minimal direct haemodynamic effects, and significantly reduced arterial blood pressure. Expand
A water-soluble, stable dipeptide NK1 receptor-selective neurokinin receptor antagonist with potent in vivo pharmacological effects: S18523.
The potassium salt of a chemically stabilized dipeptide, S18523, is described as a new water-soluble, potent and selective NK1 receptor antagonist that has strong antinociceptive effects in three classical pain tests in vivo both by i.o. and p.v. routes. Expand
Mechanisms of Pulmonary Edema Induced by an Organophosphorus Compound in Anesthetized Dogs
To determine the mechanism governing pulmonary edema induced by an organophosphorus compound, S-(2-diisopropylaminoethyl)-O-ethylmethyl phosphonothiolate (VX), lung lymph flow and lymph-to-plasma protein concentration ratio were measured before and after intravenous injection of 6 μg/kg of VX. Expand
Toxic effects of sulfur mustard on respiratory epithelial cells in culture
It is suggested that the detachment of the respiratory epithelial cells from the matrix represents a major toxic effect of 0.1 mM SM, which dramatically affects the viability of respiratory epithelium cells in culture. Expand
Effects of an organophosphorous compound on cardiac rhythm and haemodynamics in anaesthetized and conscious beagle dogs.
This study shows that, besides the expected cardiac effects resulting from muscarinic stimulation, VX can affect ventricular function through a yet unknown mechanism. Expand
An organophosphorus compound, Vx, selectively inhibits the rat cardiac Na+,K+‐ATPase α1 isoform Biochemical basis of the cardiotoxicity of Vx
As Vx had no effect on the rat kidney α1, differentially inactivated the cardiac isozymes and specifically reacted with serine residues, the putative binding‐site(s) of the organophosphorus compound on the Na+,K+‐ATPase molecules has been considered. Expand