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The renaissance of the ⁶⁸Ge/⁶⁸Ga radionuclide generator initiates new developments in ⁶⁸Ga radiopharmaceutical chemistry.
Today, one may expect that the ⁶⁸Ge/⁶⁰Ga radionuclide generator systems could contribute to and facilitate the clinical impact of nuclear medicine diagnoses for PET in a dimension comparable to the established ⁹⁹Mo/⁵⁹(m)Tc generator system for SPECT.
A triazacyclononane-based bifunctional phosphinate ligand for the preparation of multimeric 68Ga tracers for positron emission tomography.
For application in positron emission tomography (PET), PrP9, a N,N',N''-trisubstituted triazacyclononane with methyl(2-carboxyethyl)phosphinic acid pendant arms, was developed as (68)Ga(3+) complexing agent, which for the first time can be directly used for labeling purposes.
Validation and Quantification of [18F]Altanserin Binding in the Rat Brain Using Blood Input and Reference Tissue Modeling
- P. Riss, Young T. Hong, F. Aigbirhio
- BiologyJournal of cerebral blood flow and metabolism…
- 1 December 2011
The 5-hydroxytryptamine type 2a (5- HT2A) selective radiotracer [18F]altanserin has been subjected to a quantitative micro-positron emission tomography study in Lister Hooded rats and showed sufficient brain uptake in a distribution pattern consistent with the known distribution of 5-HT2A receptors.
Applications of positron emission tomography in animal models of neurological and neuropsychiatric disorders
Positron emission tomography and pharmacokinetics of 2-[18F]-fluoroethyl choline for metabolic studies in breast cancer xenografts
Abstract Background. Breast carcinomas (BC) can have abnormal choline (Cho) metabolism. Earlier studies indicated that Cho uptake can differ between different subtypes of BC. The purpose of this…
Evaluation of [18F]N-methyl-lansoprazole as a tau PET imaging agent in first-in-human studies.
Despite high affinity for tau in vitro, brain retention in MCI/AD and PSP patients was low and there was no evidence of specific signals in vivo that corresponded to tau, it is concluded that further development of [18F]NML as a tau PET imaging agent is not warranted at this time.
NODAPA-OH and NODAPA-(NCS)n: synthesis, 68Ga-radiolabelling and in vitro characterisation of novel versatile bifunctional chelators for molecular imaging.
Behavior of Supramolecular Assemblies of Radiometal-Filled and Fluorescent Carbon Nanocapsules In Vitro and In Vivo
Radiosynthesis of [18F]Trifluoroalkyl Groups: Scope and Limitations
The present paper is concerned with radiochemical methodology to furnish the trifluoromethyl motif labelled with 18F and radiochemical yields and specific activities are discussed.
Recent Development of Non-Peptide GnRH Antagonists
- Feng-Ling Tukun, D. Olberg, P. Riss, I. Haraldsen, Anita Kaass, J. Klaveness
- 1 December 2017
All developed small molecule GnRH antagonists are summarized along with the most recent clinical data and therapeutic applications for hormone-dependent diseases targeting the GnRH receptor.