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Beta-lactamase database (BLDB) – structure and function
The characterisation of representative mutants and hydrolytic profiles (kinetics) completes the picture and altogether these four elements constitute the essential foundation for a better understanding of the structure-function relationship within this enzymes family.
An histidine covalent receptor/butenolide complex mediates strigolactone perception
An undescribed mechanism of plant hormone reception where the receptor performs an irreversible enzymatic reaction to generate its own ligand is revealed.
Interconversion of ATP binding and conformational free energies by tryptophanyl-tRNA synthetase: structures of ATP bound to open and closed, pre-transition-state conformations.
Cytotoxic pentacyclic triterpenoids from Combretum sundaicum and Lantana camara as inhibitors of Bcl-xL/BakBH3 domain peptide interaction.
In an effort to discover potent inhibitors of the antiapoptotic protein Bcl-xL, a systematic in vitro evaluation was undertaken on extracts prepared from various parts of Vietnamese plants, leading to the isolation of 15 pentacyclic triterpenoids.
Protein crystallography under xenon and nitrous oxide pressure: comparison with in vivo pharmacology studies and implications for the mechanism of inhaled anesthetic action.
It is proposed that alterations of cytosolic globular protein functions by general anesthetics would be responsible for the early stages of anesthesia such as amnesia and hypnosis and that additional alterations of ion-channel membrane receptor functions are required for deeper effects that progress to "surgical" anesthesia.
Jatrophane diterpenes as inhibitors of chikungunya virus replication: structure-activity relationship and discovery of a potent lead.
The present results provide additional support for a previous hypothesis that the anti-CHIKV activity could involve a PKC-dependent mechanism and demonstrate that potency and selectivity are very sensitive to the substitution pattern on the jatrophane skeleton.
High-resolution experimental phases for tryptophanyl-tRNA synthetase (TrpRS) complexed with tryptophanyl-5'AMP.
- P. Retailleau, Y. Yin, C. Carter
- ChemistryActa crystallographica. Section D, Biological…
- 1 November 2001
Surprisingly, peak-wavelength SAD experiments produced the smallest phase errors relative to the refined structures, and changes in various structure-validation criteria arise from correcting side-chain rotamers in the core of the protein as well as on the surface.
No salting-in of lysozyme chloride observed at low ionic strength over a large range of pH.
Euphorbia dendroides Latex as a Source of Jatrophane Esters: Isolation, Structural Analysis, Conformational Study, and Anti-CHIKV Activity.
The structure-conformation relationships study of compounds 1, 5, and 6, using DFT-NMR calculations, indicated the prominent role of the acylation pattern in governing the conformational behavior of these jatrophane esters.