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SMEDWI-2 Is a PIWI-Like Protein That Regulates Planarian Stem Cells
We have identified two genes, smedwi-1 and smedwi-2, expressed in the dividing adult stem cells (neoblasts) of the planarian Schmidtea mediterranea. Both genes encode proteins that belong to theExpand
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CED-2/CrkII and CED-10/Rac control phagocytosis and cell migration in Caenorhabditis elegans
Engulfment of apoptotic cells in Caenorhabditis elegans is controlled by two partially redundant pathways. Mutations in genes in one of these pathways, defined by the genes ced-2, ced-5 and ced-10,Expand
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Identification of genes needed for regeneration, stem cell function, and tissue homeostasis by systematic gene perturbation in planaria.
Planarians have been a classic model system for the study of regeneration, tissue homeostasis, and stem cell biology for over a century, but they have not historically been accessible to extensiveExpand
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Smed-βcatenin-1 Is Required for Anteroposterior Blastema Polarity in Planarian Regeneration
Planarian flatworms can regenerate heads at anterior-facing wounds and tails at posterior-facing wounds throughout the body. How this regeneration polarity is specified has been a classic problem forExpand
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A wound-induced Wnt expression program controls planarian regeneration polarity
Regeneration requires specification of the identity of new tissues to be made. Whether this process relies only on intrinsic regulative properties of regenerating tissues or whether wound signalingExpand
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Transcriptome analysis of the planarian eye identifies ovo as a specific regulator of eye regeneration.
Among the millions of invertebrate species with visual systems, the genetic basis of eye development and function is well understood only in Drosophila melanogaster. We describe an eye transcriptomeExpand
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Planarian regeneration involves distinct stem cell responses to wounds and tissue absence.
Regeneration requires signaling from a wound site for detection of the wound and a mechanism that determines the nature of the injury to specify the appropriate regenerative response. Wound signalsExpand
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The cellular basis for animal regeneration.
The ability of animals to regenerate missing parts is a dramatic and poorly understood aspect of biology. The sources of new cells for these regenerative phenomena have been sought for decades.Expand
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Three C. elegans Rac proteins and several alternative Rac regulators control axon guidance, cell migration and apoptotic cell phagocytosis.
The Caenorhabditis elegans genome contains three rac-like genes, ced-10, mig-2, and rac-2. We report that ced-10, mig-2 and rac-2 act redundantly in axon pathfinding: inactivating one gene had littleExpand
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A Generic and Cell-Type-Specific Wound Response Precedes Regeneration in Planarians.
Regeneration starts with injury. Yet how injuries affect gene expression in different cell types and how distinct injuries differ in gene expression remain unclear. We defined the transcriptomes ofExpand
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