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SMEDWI-2 Is a PIWI-Like Protein That Regulates Planarian Stem Cells
- P. Reddien, Néstor J. Oviedo, Joya R Jennings, J. Jenkin, A. S. Alvarado
- 25 November 2005
It is suggested that SMEDWI-2 functions within dividing neoblasts to support the generation of cells that promote regeneration and homeostasis.
Clonogenic Neoblasts Are Pluripotent Adult Stem Cells That Underlie Planarian Regeneration
It is concluded that broadly distributed, adult pluripotent stem cells underlie the remarkable regenerative abilities of planarians.
Identification of genes needed for regeneration, stem cell function, and tissue homeostasis by systematic gene perturbation in planaria.
CED-2/CrkII and CED-10/Rac control phagocytosis and cell migration in Caenorhabditis elegans
It is proposed that CED-2/CrkII and Ced-5/DOCK180 function to activate CED -10/Rac in a GTPase signalling pathway that controls the polarized extension of cell surfaces.
Smed-βcatenin-1 Is Required for Anteroposterior Blastema Polarity in Planarian Regeneration
The data suggest that β-catenin specifies the posterior character of the anteroposterior axis throughout the Bilateria and specifies regeneration polarity in planarians.
A wound-induced Wnt expression program controls planarian regeneration polarity
- Christian P. Petersen, P. Reddien
- BiologyProceedings of the National Academy of Sciences
- 6 October 2009
Data indicate that wound-induced input is involved in resetting the normal polarized features of the body axis during regeneration, suggesting that the role of these genes in polarity is independent of and instructive for tail formation.
A molecular wound response program associated with regeneration initiation in planarians.
- Danielle Wenemoser, S. Lapan, Alex W. Wilkinson, G. Bell, P. Reddien
- BiologyGenes & development
- 1 May 2012
Most planarian wound-induced genes are conserved across metazoans, and identified genes and mechanisms should be important broadly for understanding wound signaling and regeneration initiation.
Three C. elegans Rac proteins and several alternative Rac regulators control axon guidance, cell migration and apoptotic cell phagocytosis.
Three distinct regulatory proteins modulate Rac activation and function in different developmental processes in Caenorhabditis elegans are reported.
The cellular basis for animal regeneration.