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- Publications
- Influence
SMEDWI-2 Is a PIWI-Like Protein That Regulates Planarian Stem Cells
- P. Reddien, Néstor J. Oviedo, Joya R Jennings, J. Jenkin, Alejandro Sánchez Alvarado
- Biology, Medicine
- Science
- 25 November 2005
We have identified two genes, smedwi-1 and smedwi-2, expressed in the dividing adult stem cells (neoblasts) of the planarian Schmidtea mediterranea. Both genes encode proteins that belong to the… Expand
CED-2/CrkII and CED-10/Rac control phagocytosis and cell migration in Caenorhabditis elegans
- P. Reddien, H. Horvitz
- Biology, Medicine
- Nature Cell Biology
- 1 March 2000
Engulfment of apoptotic cells in Caenorhabditis elegans is controlled by two partially redundant pathways. Mutations in genes in one of these pathways, defined by the genes ced-2, ced-5 and ced-10,… Expand
Identification of genes needed for regeneration, stem cell function, and tissue homeostasis by systematic gene perturbation in planaria.
- P. Reddien, Adam L. Bermange, Kenneth J. Murfitt, Joya R Jennings, A. Sánchez Alvarado
- Biology, Medicine
- Developmental cell
- 1 May 2005
Planarians have been a classic model system for the study of regeneration, tissue homeostasis, and stem cell biology for over a century, but they have not historically been accessible to extensive… Expand
Smed-βcatenin-1 Is Required for Anteroposterior Blastema Polarity in Planarian Regeneration
- C. P. Petersen, P. Reddien
- Biology, Medicine
- Science
- 18 January 2008
Planarian flatworms can regenerate heads at anterior-facing wounds and tails at posterior-facing wounds throughout the body. How this regeneration polarity is specified has been a classic problem for… Expand
A wound-induced Wnt expression program controls planarian regeneration polarity
- C. P. Petersen, P. Reddien
- Biology, Medicine
- Proceedings of the National Academy of Sciences
- 6 October 2009
Regeneration requires specification of the identity of new tissues to be made. Whether this process relies only on intrinsic regulative properties of regenerating tissues or whether wound signaling… Expand
Transcriptome analysis of the planarian eye identifies ovo as a specific regulator of eye regeneration.
- Sylvain W. Lapan, P. Reddien
- Biology, Medicine
- Cell reports
- 1 August 2012
Among the millions of invertebrate species with visual systems, the genetic basis of eye development and function is well understood only in Drosophila melanogaster. We describe an eye transcriptome… Expand
Planarian regeneration involves distinct stem cell responses to wounds and tissue absence.
- D. Wenemoser, P. Reddien
- Biology, Medicine
- Developmental biology
- 1 June 2010
Regeneration requires signaling from a wound site for detection of the wound and a mechanism that determines the nature of the injury to specify the appropriate regenerative response. Wound signals… Expand
The cellular basis for animal regeneration.
- E. Tanaka, P. Reddien
- Biology, Medicine
- Developmental cell
- 1 July 2011
The ability of animals to regenerate missing parts is a dramatic and poorly understood aspect of biology. The sources of new cells for these regenerative phenomena have been sought for decades.… Expand
Three C. elegans Rac proteins and several alternative Rac regulators control axon guidance, cell migration and apoptotic cell phagocytosis.
- E. Lundquist, P. Reddien, E. Hartwieg, H. Horvitz, C. Bargmann
- Biology, Medicine
- Development
- 15 November 2001
The Caenorhabditis elegans genome contains three rac-like genes, ced-10, mig-2, and rac-2. We report that ced-10, mig-2 and rac-2 act redundantly in axon pathfinding: inactivating one gene had little… Expand
A Generic and Cell-Type-Specific Wound Response Precedes Regeneration in Planarians.
- O. Wurtzel, Lauren E Cote, Amber Poirier, R. Satija, A. Regev, P. Reddien
- Biology, Medicine
- Developmental cell
- 1 December 2015
Regeneration starts with injury. Yet how injuries affect gene expression in different cell types and how distinct injuries differ in gene expression remain unclear. We defined the transcriptomes of… Expand