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piRNA Production Requires Heterochromatin Formation in Drosophila
TLDR
This work shows that deposition of histone 3 lysine 9 by the methyltransferase dSETDB1 (egg) is required for piRNA cluster transcription and proposes that heterochromatin protects the germline by activating the piRNA pathway. Expand
Temporal and Spatial Control of Germ-Plasm RNAs
TLDR
A role for 3'UTR mediated translational regulation in fine-tuning the temporal expression of localized RNA is demonstrated and may provide a paradigm for other RNAs that are found enriched at distinct cellular locations such as the leading edge of fibroblasts or the neuronal synapse. Expand
Assembly of core helices and rapid tertiary folding of a small bacterial group I ribozyme
TLDR
Ribonuclease and hydroxyl radical cleavage protection assays showed that base pairing of core helices stabilize a compact state of a small group I ribozyme from Azoarcus pre-tRNAile, indicating that assembly of helices in the catalytic core represents a distinct phase that precedes the formation of native tertiary structure. Expand
Germ Cells Are Forever
Germ cells are the only cell type capable of generating an entirely new organism. In order to execute germline-specific functions and to retain the capacity for totipotency, germ cells repressExpand
RNA tertiary interactions mediate native collapse of a bacterial group I ribozyme.
TLDR
These results show that native tertiary interactions stabilize the compact folding intermediates under conditions in which the RNA backbone remains accessible to solvent. Expand
Architecture and folding mechanism of the Azoarcus Group I Pre-tRNA.
TLDR
The conformation of a group I pre-tRNA(ile) from the bacterium Azoarcus was probed by ribonuclease T(1) and hydroxyl radical cleavage, and by native gel electrophoresis, and showed that the tRNA is folded, and thatThe tRNA and intron sequences form separate tertiary domains. Expand
Transposon Dysregulation Modulates dWnt4 Signaling to Control Germline Stem Cell Differentiation in Drosophila
TLDR
A chromatin-transposon-Wnt signaling axis that regulates stem cell fate is revealed and it is found that independent upregulation of TEs also downregulated dWnt4, leading to GSC differentiation defects. Expand
Compaction of a bacterial group I ribozyme coincides with the assembly of core helices.
TLDR
Expectation that monovalent ions not only are less efficient in charge neutralization but also contract the RNA less efficiently than multivalent ions is confirmed. Expand
Structural requirement for Mg2+ binding in the group I intron core.
TLDR
Ribonuclease and hydroxyl radical footprinting of a small group I intron from Azoarcus pre-tRNA(Ile) showed that tertiary interactions between helical domains are stable in a variety of cations. Expand
Structural rearrangements linked to global folding pathways of the Azoarcus group I ribozyme.
TLDR
The footprinting results show that 50-60% of the modified ribozyme folds in less than 30 ms, while the rest of the RNA population undergoes slow structural rearrangements that control the global folding rate. Expand
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