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JNK-associated Leucine Zipper Protein Functions as a Docking Platform for Polo-like Kinase 1 and Regulation of the Associating Transcription Factor Forkhead Box Protein K1*
Background: The role of JLP in cell signaling is not well defined. Results: JLP interacts with PLK1 and FOXK1 during mitosis, and ablation of JLP leads to increased FOXK1 protein levels. Conclusion:Expand
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Discovery of 2-(1H-indol-5-ylamino)-6-(2,4-difluorophenylsulfonyl)-8-methylpyrido[2,3-d]pyrimidin-7(8H)-one (7ao) as a potent selective inhibitor of Polo like kinase 2 (PLK2).
Several families of protein kinases have been shown to play a critical role in the regulation of cell cycle progression, particularly progression through mitosis. These kinase families include theExpand
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Generation and characterization of novel monoclonal antibodies recognizing UBXD1.
UBXD1 is a recently identified adaptor for p97, a highly abundant and conserved member of the AAA family of ATPase that plays pivotal roles in a multitude of cellular processes involving theExpand
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CRISPR-based screens uncover determinants of immunotherapy response in Multiple Myeloma
Cancer cells commonly develop resistance to immunotherapy by loss of antigen expression. Combinatorial treatments that increase levels of the target antigen on the surface of cancer cells have theExpand
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CRISPR-based genetic interaction maps inform therapeutic strategies in cancer.
The future of cancer precision medicine lies in the rational design of effective therapies tailored to each patient based on the genetic makeup of their tumor. While the investigation of cancerExpand
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CRISPR-based screens uncover determinants of immunotherapy response in multiple myeloma.
Cancer cells commonly develop resistance to immunotherapy by loss of antigen expression. Combinatorial treatments that increase levels of the target antigen on the surface of cancer cells have theExpand
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P33-22 Advances in analysis of spontaneous EEG/MEG activity by independent component analysis
Objective: To clarify the cerebral mechanism of proprioceptive sensation in human Methods: Thirteen right handed healthy volunteers participated. We used a newly developed device to produce brisk butExpand
Interaction of JLP with Plk1 recruits FoxK1 to interact and form a ternary complex
JLP (JNK associated Leucine zipper protein) is a scaffolding protein, which has been shown to interact with and activate JNK/p38MAPK pathway. Its interaction with various signaling proteins isExpand
Synthesis, characterization and structural modification of NanophilicPoly(epichlorohydrin)
The solution polymerization of epichlorohydrin (ECH) in the presence of thioglycolicacid (TGA) as an initiator at 45oC for four hours under nitrogen atmosphere was carried out. Further, the structureExpand