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Specification of cerebral cortical areas.
- P. Rakic
- 8 July 1988
The radial unit model provides a framework for understanding cerebral evolution, epigenetic regulation of the parcellation of cytoarchitectonic areas, and insight into the pathogenesis of certain cortical disorders in humans.
A small step for the cell, a giant leap for mankind: a hypothesis of neocortical expansion during evolution
- P. Rakic
- BiologyTrends in Neurosciences
- 1 September 1995
Evolution of the neocortex: a perspective from developmental biology
- P. Rakic
- Biology, PsychologyNature Reviews Neuroscience
- 1 October 2009
How novelties that make us human may have been introduced during evolution are described, based on findings in the embryonic cerebral cortex in different mammalian species.
Development of the human cerebral cortex: Boulder Committee revisited
Current data on the development of the human cerebral cortex is reviewed and the classical model of how the structure that makes us human is formed is updated.
Absence of excitotoxicity-induced apoptosis in the hippocampus of mice lacking the Jnk3 gene
It is reported that disruption of the gene encoding Jnk3 in mice caused the mice to be resistant to the excitotoxic glutamate-receptor agonist kainic acid and neuroprotection was prevented: they showed a reduction in seizure activity and hippocampal neuron apoptosis was prevented.
Decreased apoptosis in the brain and premature lethality in CPP32-deficient mice
CPP32 is shown to play a critical role during morphogenetic cell death in the mammalian brain during embryonic day 12, resulting in a variety of hyperplasias and disorganized cell deployment.
Origin of GABAergic neurons in the human neocortex
It is suggested that modifications in the expression pattern of transcription factors in the forebrain may underlie species-specific programmes for the generation of neocortical local circuit neurons and that distinct lineages of cortical interneurons may be differentially affected in genetic and acquired diseases of the human brain.
Extraordinary neoteny of synaptic spines in the human prefrontal cortex
- Z. Petanjek, M. Judas, I. Kostović
- Biology, PsychologyProceedings of the National Academy of Sciences
- 25 July 2011
Evidence is obtained that overproduction and developmental remodeling, including substantial elimination of synaptic spines, continues beyond adolescence and throughout the third decade of life before stabilizing at the adult level, which has implications for understanding the effect of environmental impact on the development of human cognitive and emotional capacities.
The Jnk1 and Jnk2 Protein Kinases Are Required for Regional Specific Apoptosis during Early Brain Development
Identification of a multipotent astrocytic stem cell in the immature and adult mouse brain.
- E. Laywell, P. Rakic, V. Kukekov, E. Holland, D. Steindler
- BiologyProceedings of the National Academy of Sciences…
- 5 December 2000
It is concluded that environmental factors, simulated by certain in vitro conditions, transiently confer NSC-like attributes on astrocytes during a critical period in CNS development.