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Visual transduction in Drosophila
TLDR
Phototransduction in flies represents the fastest G-protein-signalling cascade known and analysis in Drosophila has revealed many of the underlying molecular strategies, leading to the discovery and characterization of signalling molecules of widespread importance. Expand
Polyunsaturated fatty acids activate the Drosophila light-sensitive channels TRP and TRPL
TLDR
It is suggested that another polyunsaturated fatty acid, such as linolenic acid, may be a messenger of excitation in Drosophila photoreceptors, as four different lipoxygenase inhibitors, which might be expected to lead to build-up of endogenous fatty acids, also activate native TRP and TRPL channels in intact photoresceptors. Expand
Calcium Influx via TRP Channels Is Required to Maintain PIP2 Levels in Drosophila Photoreceptors
TLDR
The results suggest that Ca2+ influx prevents PIP2 depletion by inhibiting PLC activity and facilitating PIP1 recycling and preventing inactivation in trp. Expand
Molecular Basis of Amplification in Drosophila Phototransduction Roles for G Protein, Phospholipase C, and Diacylglycerol Kinase
TLDR
It is found that quantum bumps in mutants with greatly reduced levels of either G protein or PLC are reduced but are restored to near wild-type values by mutations in the rdgA gene encoding diacylglycerol kinase (DGK) and also by depleting intracellular ATP. Expand
Constitutive Activity of the Light-Sensitive Channels TRP and TRPL in the Drosophila Diacylglycerol Kinase Mutant, rdgA
TLDR
The findings suggest that early degeneration in rdgA is caused by uncontrolled Ca2+ influx and support the proposal that diacylglycerol or its metabolites are messengers of excitation in Drosophila photoreceptors. Expand
Rhabdomere biogenesis in Drosophila photoreceptors is acutely sensitive to phosphatidic acid levels
TLDR
Before a critical time period during rhabdomere biogenesis in Drosophila melanogaster photoreceptors, elevated levels of PA disrupt membrane transport to the apical domain. Expand
A dPIP5K Dependent Pool of Phosphatidylinositol 4,5 Bisphosphate (PIP2) Is Required for G-Protein Coupled Signal Transduction in Drosophila Photoreceptors
TLDR
The results provide evidence for the existence of a unique dPIP5K dependent pool of PIP2 required for normal Drosophila phototransduction as defined by distinct lipid kinases and supporting specific molecular processes at neuronal membranes. Expand
Normal Phototransduction in Drosophila Photoreceptors Lacking an InsP3 Receptor Gene
TLDR
Results indicate that InsP(3)R-mediated store depletion does not underlie TRP and TRPL activation in Drosophila photoreceptors, and using the specific TRP channel blocker La(3+) it is demonstrated that both TRP or TRPL channel functions were unaffected. Expand
Emerging findings from studies of phospholipase D in model organisms (and a short update on phosphatidic acid effectors).
TLDR
What is known about phospholipase D in several model organisms, including C. elegans, Dictyostelium and Drosophila, is summarized and a short update on phosphatidic acid targets is provided, a topic last reviewed in 2006. Expand
RDGBα, a PtdIns-PtdOH transfer protein, regulates G-protein-coupled PtdIns(4,5)P2 signalling during Drosophila phototransduction
TLDR
RDGB regulates PtdIns and PTDIns(4,5)P2 homeostasis during G-protein-activated phospholipase C signalling in Drosophila and couples the turnover of both Ptd Ins and PtdOH, key lipid intermediates during G -protein-coupled Ptd inservice 4,5-bisphosphate turnover. Expand
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