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Nrf2 regulates ROS production by mitochondria and NADPH oxidase
Background Nuclear factor (erythroid-derived 2) factor 2 (Nrf2) is a crucial transcription factor mediating protection against oxidants. Nrf2 is negatively regulated by cytoplasmic Kelch-like ECHExpand
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Functional Oxygen Sensitivity of Astrocytes
In terrestrial mammals, the oxygen storage capacity of the CNS is limited, and neuronal function is rapidly impaired if oxygen supply is interrupted even for a short period of time. However, oxygenExpand
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Loss of PLA2G6 leads to elevated mitochondrial lipid peroxidation and mitochondrial dysfunction
Mutations in PLA2G6, which encodes ‘calcium-independent phospholipase A2 beta’, have been implicated in parkinsonian disorders. Kinghorn et al. show, in a Drosophila model and in human fibroblasts,Expand
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Mutations in HPCA Cause Autosomal-Recessive Primary Isolated Dystonia
Reports of primary isolated dystonia inherited in an autosomal-recessive (AR) manner, often lumped together as “DYT2 dystonia,” have appeared in the scientific literature for several decades, but noExpand
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Nrf2 affects the efficiency of mitochondrial fatty acid oxidation.
Transcription factor Nrf2 (NF-E2 p45-related factor 2) regulates the cellular redox homoeostasis and cytoprotective responses, allowing adaptation and survival under conditions of stress. TheExpand
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Loss of PINK1 Increases the Heart's Vulnerability to Ischemia-Reperfusion Injury
Objectives Mutations in PTEN inducible kinase-1 (PINK1) induce mitochondrial dysfunction in dopaminergic neurons resulting in an inherited form of Parkinson’s disease. Although PINK1 is present inExpand
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Aggregated α-synuclein and complex I deficiency: exploration of their relationship in differentiated neurons
α-Synuclein becomes misfolded and aggregated upon damage by various factors, for example, by reactive oxygen species. These aggregated forms have been proposed to have differential toxicities andExpand
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Monomeric Alpha-Synuclein Exerts a Physiological Role on Brain ATP Synthase
Misfolded α-synuclein is a key factor in the pathogenesis of Parkinson's disease (PD). However, knowledge about a physiological role for the native, unfolded α-synuclein is limited. Using brains ofExpand
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Role of mitochondrial ROS in the brain: from physiology to neurodegeneration
Mitochondria are key cell organelles in that they are responsible for energy production and control many processes from signalling to cell death. The function of the mitochondrial electron transportExpand
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Enhancing nucleotide metabolism protects against mitochondrial dysfunction and neurodegeneration in a PINK1 model of Parkinson’s disease
Mutations in PINK1 cause early-onset Parkinson’s disease (PD). Studies in Drosophila melanogaster have highlighted mitochondrial dysfunction on loss of Pink1 as a central mechanism of PDExpand
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