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Inhibition of transcription factor NF-kappaB by sesquiterpene lactones: a proposed molecular mechanism of action.
Quantitative structure-activity relationship of sesquiterpene lactones as inhibitors of the transcription factor NF-kappaB.
- B. Siedle, A. García-Piñeres, I. Merfort
- Chemistry, BiologyJournal of medicinal chemistry
- 19 October 2004
This work investigates a set of 103 different sesquiterpene lactones representing 6 structural groups for their NF-kappaB inhibiting properties and the resulting IC(100)-values were submitted to a QSAR study.
Study of three sesquiterpene lactones from Tithonia diversifolia on their anti-inflammatory activity using the transcription factor NF-kappa B and enzymes of the arachidonic acid pathway as targets.
It is shown that the main sesquiterpene lactones of this species growing in Costa Rica do not influence the enzymes of the arachidonic acid pathway, but inhibit the activation of NF-kappa B.
Inhibition of inflammatory cytokine production and lymphocyte proliferation by structurally different sesquiterpene lactones correlates with their effect on activation of NF-kappaB.
Study of sesquiterpene lactones from Milleria quinqueflora on their anti-inflammatory activity using the transcription factor NF-kappa B as molecular target.
Anti-inflammatory activities of hypocretenolides from Leontodon hispidus.
14-Hydroxyhypocretenolide-beta-D-glucoside-4'-14"-hydroxyhypocr etenoate as well as its aglycone exhibited activity in both test systems, whereas the D-gl Sucoside was not or only weakly active.
Germacranolides from Mikania guaco.