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Short-term endpoints of conventional versus laparoscopic-assisted surgery in patients with colorectal cancer (MRC CLASICC trial): multicentre, randomised controlled trial
TLDR
Laroscopic-assisted surgery for cancer of the colon is as effective as open surgery in the short term and is likely to produce similar long-term outcomes, however, impaired short- term outcomes after laparosc-assisted anterior resection forcancer of the rectum do not yet justify its routine use. Expand
Preoperative radiotherapy versus selective postoperative chemoradiotherapy in patients with rectal cancer (MRC CR07 and NCIC-CTG C016): a multicentre, randomised trial
TLDR
Results from this randomised trial provide convincing and consistent evidence that short-course preoperative radiotherapy is an effective treatment for patients with operable rectal cancer. Expand
LOCAL RECURRENCE OF RECTAL ADENOCARCINOMA DUE TO INADEQUATE SURGICAL RESECTION Histopathological Study of Lateral Tumour Spread and Surgical Excision
In 52 patients with rectal adenocarcinoma whole-mount sections of the entire operative specimen were examined by transverse slicing. There was spread to the lateral resection margin in 14 of 52 (27%)Expand
Randomized trial of laparoscopic-assisted resection of colorectal carcinoma: 3-year results of the UK MRC CLASICC Trial Group.
TLDR
Long-term outcomes for patients with rectal cancer were similar in those undergoing abdominoperineal resection and AR, and support the continued use of laparoscopic surgery in these patients. Expand
What is the role for the circumferential margin in the modern treatment of rectal cancer?
TLDR
It is demonstrated that, after neoadjuvant therapy (both radiotherapy and radiochemotherapy), the predictive value of the CRM for local recurrence is significantly higher than when no preoperative therapy has been applied and involvement is one of the key factors in rectal cancer treatment. Expand
WISP genes are members of the connective tissue growth factor family that are up-regulated in wnt-1-transformed cells and aberrantly expressed in human colon tumors.
TLDR
The identification of two genes, WISP-1 and W ISP-2, that are up-regulated in the mouse mammary epithelial cell line C57MG transformed by Wnt-1, but not by Wnnt-4 are reported, suggesting that the WISp genes may be downstream of WNT-1 signaling and that aberrant levels of WISPs expression in colon cancer may play a role in colon tumorigenesis. Expand
Effect of the plane of surgery achieved on local recurrence in patients with operable rectal cancer: a prospective study using data from the MRC CR07 and NCIC-CTG CO16 randomised clinical trial
TLDR
In rectal cancer, the plane of surgery achieved is an important prognostic factor for local recurrence, and both a negative circumferential resection margin and a superior plane of Surgery achieved were associated with lowLocal recurrence rates. Expand
Value of mismatch repair, KRAS, and BRAF mutations in predicting recurrence and benefits from chemotherapy in colorectal cancer.
TLDR
The usefulness of defective mismatch repair, BRAF, and KRAS mutations in predicting tumor recurrence and sensitivity to chemotherapy is investigated and MMR assays identify patients with a low risk of recurrence. Expand
Kirsten ras mutations in patients with colorectal cancer: the ‘RASCAL II’ study
TLDR
It is suggested that not only is the presence of a codon 12 glycine to valine mutation important for cancer progression but also that it may predispose to more aggressive biological behaviour in patients with advanced colorectal cancer. Expand
Macroscopic evaluation of rectal cancer resection specimen: clinical significance of the pathologist in quality control.
TLDR
Criteria by which pathologists can judge the quality or completeness of the resection specimen in a randomized trial for rectal cancer is evaluated and a new role of the pathologist in quality control is established. Expand
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