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Myocardin Enhances Smad3-Mediated Transforming Growth Factor-β1 Signaling in a CArG Box-Independent Manner: Smad-Binding Element Is an Important cis Element for SM22α Transcription In Vivo
It is shown that mutation of the SBE reduces the activation potential of a SM22α promoter in transgenic mice during embryogenesis and is the first demonstration that Myocd can act as a transcriptional coactivator of the smooth muscle regulatory network in a CArG box-independent manner. Expand
Interaction of Smad3 and SRF-associated complex mediates TGF-beta1 signals to regulate SM22 transcription during myofibroblast differentiation.
- P. Qiu, Xin-Hua Feng, L. Li
- Biology, Medicine
- Journal of molecular and cellular cardiology
- 1 December 2003
These findings provide the first evidence that Smad3 directly links TGF-beta1 signaling to an SRF-associated regulatory network in controlling SM22 transcription; it also implies that T GF- beta1 regulates the SM22 promoter via Smad 3-dependent and SmAD3-independent pathways. Expand
Thymosin beta 4 suppression of corneal NFkappaB: a potential anti-inflammatory pathway.
- G. Sosne, P. Qiu, P. Christopherson, M. Wheater
- Biology, Medicine
- Experimental eye research
- 1 April 2007
Tbeta4, a protein with diverse cellular functions including wound healing and suppression of inflammation, inhibits the activation of NFkappaB in TNF-alpha-stimulated cells, which has important clinical implications for the potential role of Tbeta4 as a corneal anti-inflammatory agent. Expand
Gefitinib resistance resulted from STAT3-mediated Akt activation in lung cancer cells
Combinational targeting on both EGFR and STAT3 may enhance the efficacy of gefitinib or other EGFR TKIs in lung cancer and suggest that activation of STAT3 is an intrinsic mechanism of drug resistance in response to EGFRTKIs. Expand
Histone Acetylation and Recruitment of Serum Responsive Factor and CREB-Binding Protein Onto SM22 Promoter During SM22 Gene Expression
Evidence that chromatin acetylation is involved in smooth muscle cell-specific gene regulation is provided by showing that the stimulation of the SM22 promoter by the coactivator CREB-binding protein (CBP) was dependent on HAT activity. Expand
Differentiation defect in neural crest-derived smooth muscle cells in patients with aortopathy associated with bicuspid aortic valves
It is demonstrated that decreased differentiation and contraction of patient's NCSC-derived SMCs may contribute to that aortopathy associated with BAV, and inhibited mTOR pathway using rapamycin rescued the aberrant differentiation. Expand
Carcinogenic metalloid arsenic induces expression of mdig oncogene through JNK and STAT3 activation.
The data suggest that mdig may play important roles on the pathogenesis of arsenic- induced lung cancer and that JNK and STAT3 signaling pathways are essential in mediating arsenic-induced mdig expression. Expand
Yes‐Associated Protein Inhibits Transcription of Myocardin and Attenuates Differentiation of Vascular Smooth Muscle Cell from Cardiovascular Progenitor Cell Lineage
YAP negatively regulates differentiation of VSMCs from CVPCs by decreasing transcription of myocardin in a NKX2.5‐dependent manner. Expand
Biological activities of thymosin ß4 defined by active sites in short peptide sequences
- G. Sosne, P. Qiu, A. Goldstein, M. Wheater
- Biology, Medicine
- FASEB journal : official publication of the…
- 1 July 2010
Thymosin ß4, a small ubiquitous protein containing 43 aa, has structure/function activity via its actin‐binding domain and numerous biological affects on cells, and several active sites with unique functions have been identified. Expand
Thymosin beta4 is cytoprotective in human gingival fibroblasts.
- R. Reti, E. Kwon, P. Qiu, M. Wheater, G. Sosne
- Chemistry, Medicine
- European journal of oral sciences
- 1 October 2008
Thymosin beta 4 significantly suppressed the secretion of interleukin-8 (IL-8) following stimulation with tumor necrosis factoralpha (TNF-alpha), suggesting that it may suppress the inflammatory response initiated by pro-inflammatory cytokines. Expand