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Rapid and quantitative detection of human adenovirus DNA by real‐time PCR
TLDR
Real‐time PCR with consensus primer and probe sequences for a conserved region of the hexon gene is designed and evaluated and is found to be a sensitive and quantitative procedure for the detection of adenovirus infections. Expand
Evolution of poliovirus type I during 5.5 years of prolonged enteral replication in an immunodeficient patient.
TLDR
Poliovirus type 1 was isolated from an immunodeficient patient 4 days after onset of paresis and after 5.5 years of prolonged enteral virus replication, revealing that IS1 was Sabin 1-like, whereas IS2 reacted like poliovirus 1 Mahoney. Expand
Adenovirus Type 37 Uses Sialic Acid as a Cellular Receptor on Chang C Cells
TLDR
It is demonstrated that enzymatic removal or lectin-mediated blocking of cell surface sialic acid inhibits the binding of Ad37 virions to Chang C cells, as does soluble, virion-interacting sialIC acid-containing substances, which concludes that Ad37 uses siali acid as a major receptor in cell lines derived from both genital and corneal tissues. Expand
Adenovirus type 37 binds to cell surface sialic acid through a charge-dependent interaction.
TLDR
The results presented provide strong evidence for a charge mechanism during the interaction between the Ad37 fiber knob and sialic acid. Expand
Multiplex polymerase chain reaction for subgenus‐specific detection of human adenoviruses in clinical samples
TLDR
The six subgenus‐specific amplimers are distinguishable by agarose gel electrophoresis, and subsequent restriction analysis is not necessary, and could also facilitate the primary classification of unknown virus isolates. Expand
Characterization of adenovirus subgenus D fiber genes.
TLDR
The hypothesis that intermediate strains arise by recombination of two serologically different parent viruses is supported and several highly conserved sequences could be confirmed. Expand
PCR-based detection and typing of human adenoviruses in clinical samples.
TLDR
To extend the technique of type- specific PCR to other adenovirus serotypes, type-specific primers for Ad1, Ad2, Ad4, Ad5, Ad19 and Ad37 were evaluated and could be detected in 42 stool and 47 eye swab samples. Expand
Complement activation by recombinant adenoviruses
TLDR
It is suggested that complement activation can be ignored in local low-dose applications of recombinant adenoviruses, but warrants attention after systemic application of large viral quantities, as well as in clinical protocols aiming at systemic virus application. Expand
Type- and group-specific polymerase chain reaction for adenovirus detection.
TLDR
Comparison of the hexon sequences showed that the major sequence changes were located in loops I1 and I2 of the Hexon polypeptides which form the surface of the virion. Expand
The hexon genes of adenoviruses of subgenus C: comparison of the variable regions.
TLDR
Alignment of the amino acid sequences to the known 3-dimensional structure of the AV2 hexon demonstrated that the major amino acid changes were located in the L1 and L2 loops that form the surface of the hexon. Expand
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