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M Channels Containing KCNQ2 Subunits Modulate Norepinephrine, Aspartate, and GABA Release from Hippocampal Nerve Terminals
Findings provide novel evidence for a major regulatory role of KCNQ2 K+ channel subunits in neurotransmitter release from rat hippocampal nerve endings. Expand
Isoniazid: metabolic aspects and toxicological correlates.
  • P. Preziosi
  • Chemistry, Medicine
  • Current drug metabolism
  • 30 November 2007
INH, HZ and its mono- and diacetylated metabolites, and ammonia are examined in terms of their potential to cause neurotoxic and hepatotoxic effects (the two major forms of INH toxicity observed in animals and humans). Expand
The secondary alcohol metabolite of doxorubicin irreversibly inactivates aconitase/iron regulatory protein‐1 in cytosolic fractions from human myocardium
It is demonstrated thatDOXol delocalizes low molecular weight Fe(II) from the [4Fe‐4S] cluster of cytoplasmic aconitase, suggesting that intramyocardial formation of DOXol may perturb the homeostatic processes associated with cluster assembly or disassembly and the reversible switch between acon itase and IRP‐1. Expand
[Chronic cor pulmonale].
Erythropoietin exerts anti‐apoptotic effects on rat microglial cells in vitro
The effects of EPO on primary cultures of rat cortical microglia and astrocytes are investigated and it is found that the cytokine increased microglial cell population size in a concentration‐dependent manner, but EPO did not affect the pro‐inflammatory function ofmicroglial cells. Expand
Oxidative and nitrosative modifications of biliverdin reductase-A in the brain of subjects with Alzheimer's disease and amnestic mild cognitive impairment.
Nitrosative stress-induced modifications on hippocampal BVR-A are an early event in the pathogenesis of AD since they appear also in MCI subjects and could contribute to the antioxidant and metabolic derangement characteristic of these neurodegenerative disorders. Expand
Involvement of KCNQ2 subunits in [3H]dopamine release triggered by depolarization and pre‐synaptic muscarinic receptor activation from rat striatal synaptosomes
Findings indicate that, in rat striatal nerve endings, IKM channels containing KCNQ2 subunits regulate depolarization‐induced DA release and that IKKM suppression is involved in the reinforcement of depolarized‐inducedDA release triggered by the activation of pre‐synaptic muscarinic heteroreceptors. Expand
Bacterial lipopolysaccharide increases prostaglandin production by rat astrocytes via inducible cyclo-oxygenase: evidence for the involvement of nuclear factor kappaB.
It was found that LPS produced a concentration-dependent increase in PGE2 release from astrocytes, and nuclear factor kappaB appears to play a role in the activation of COX-2 induced by LPS. Expand
Inhibition of lipid peroxidation and protein oxidation by endogenous and exogenous antioxidants in rat brain microsomes in vitro
Both bilirubin and biliverdin exhibited a greater antioxidant activity than alpha-tocopherol in preventing oxidative stress damage in rat brain. Expand
Evidence that carbon monoxide stimulates prostaglandin endoperoxide synthase activity in rat hypothalamic explants and in primary cultures of rat hypothalamic astrocytes.
Evidence presented here suggests that the catabolism of endogenous or exogenously added hemin is associated with an increase in PGE2 production in the rat hypothalamus, and at least some of the biological effects of CO at the hypothalamic level might be mediated by the activation of the PGHS pathway. Expand