Share This Author
A human homologue of the Drosophila Toll protein signals activation of adaptive immunity
The cloning and characterization of a human homologue of the Drosophila toll protein (Toll) is reported, which has been shown to induce the innate immune response in adult Dosophila.
MyD88 is an adaptor protein in the hToll/IL-1 receptor family signaling pathways.
On the complexity of self
Data suggest that self peptides presented by self MHC class II molecules at densities sufficient to signal a CD4 T cell are of very limited complexity, as Y-Ae stains antigen presenting cells that mediate negative selection but not thymic cortical epithelial cells5 that drive positive selection3.
Sequence analysis of peptides bound to MHC class II molecules
- A. Rudensky, P. Preston-Hurlburt, Soon‐Cheol Hong, A. Barlow, C. Janeway
- 17 October 1991
The finding of predominant self peptides has interesting implications for antigen processing and self–non-self discrimination.
Immune responses to SARS-CoV-2 infection in hospitalized pediatric and adult patients
- Carl A. Pierce, P. Preston-Hurlburt, B. Herold
- Medicine, BiologyScience Translational Medicine
- 21 September 2020
The findings suggest that the poor outcome in hospitalized adults with COVID-19 compared to children may not be attributable to a failure to generate adaptive immune responses, and age-dependent factors may modulate the antiviral immune response.
The specificity and orientation of a TCR to its peptide-MHC class II ligands.
Specific peripheral B cell tolerance defects in patients with multiple sclerosis.
- T. Kinnunen, Nicolas Chamberlain, E. Meffre
- Medicine, BiologyThe Journal of clinical investigation
- 3 June 2013
It is demonstrated that in contrast to patients with RA or T1D, bone marrow central B cell selection in MS appears normal in most patients, and patients with MS suffer from a specific peripheral B cell tolerance defect that is potentially attributable to impaired Treg function and that leads to the accumulation of autoreactive B cell clones in their blood.
RAGE Expression in Human T Cells: A Link between Environmental Factors and Adaptive Immune Responses
It is found that RAGE is expressed intracellularly in human T cells following TCR activation but constitutively on T cells from patients with diabetes, and a role for this receptor and its ligands in modulating human immune responses is identified.
Teplizumab Induces Human Gut-Tropic Regulatory Cells in Humanized Mice and Patients
- F. Waldron-Lynch, O. Henegariu, K. Herold
- Biology, MedicineScience Translational Medicine
- 25 January 2012
The findings demonstrate that humanized mice may be used to identify novel immunologic mechanisms that occur in patients treated with immunomodulators, and suggest mechanisms of drug action in murine models that have not been confirmed in clinical studies.
Synergistic Reversal of Type 1 Diabetes in NOD Mice With Anti-CD3 and Interleukin-1 Blockade
The studies indicate that the combination of anti-CD3 mAb with IL-1RA is synergistic in reversal of diabetes through a combination of mechanisms, which causes persistent remission from islet inflammation.