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Pilin glycosylation in Neisseria meningitidis occurs by a similar pathway to wzy-dependent O-antigen biosynthesis in Escherichia coli.
Pili (type IV fimbriae) of Neisseria meningitidis are glycosylated by the addition of O-linked sugars. Recent work has shown that PglF, a protein with homology to O-antigen 'flippases', is requiredExpand
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Genetic characterization of pilin glycosylation and phase variation in Neisseria meningitidis
Pili of Neisseria meningitidis are a key virulence factor, being the major adhesin of this capsulate organism and contributing to specificity for the human host. Pili are post‐translationallyExpand
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Sequence and functional analyses of Haemophilus spp. genomic islands
BackgroundA major part of horizontal gene transfer that contributes to the diversification and adaptation of bacteria is facilitated by genomic islands. The evolution of these islands is poorlyExpand
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Genetic characterization of pilin glycosylation in Neisseria meningitidis.
Pili of Neisseria meningitidis are a key virulence factor, being the major adhesin of this capsulate organism and contributing to specificity for the human host. Pili are post-translationallyExpand
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Lineage-specific Virulence Determinants of Haemophilus influenzae Biogroup aegyptius
Novel adhesions, including trimeric autotransporters, might contribute to virulence.
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The genetics of glycosylation in Gram-negative bacteria.
In recent years there has been a dramatic increase in reports of glycosylation of proteins in various Gram-negative systems including Neisseria meningitidis, Neisseria gonorrhoeae, CampylobacterExpand
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The pilin O-glycosylation pathway of pathogenic Neisseria is a general system that glycosylates AniA, an outer membrane nitrite reductase.
O-Glycosylation is emerging as a common posttranslational modification of surface exposed proteins in bacterial mucosal pathogens. In pathogenic Neisseria an O-glycosylation pathway modifies a singleExpand
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Simple sequence repeats in Haemophilus influenzae
Simple sequence repeat (SSRs) of DNA are subject to high rates of mutation and are important mediators of adaptation in Haemophilus influenzae. Previous studies of the Rd KW20 genome identified theExpand
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Identification of Bacterial Protein O-Oligosaccharyltransferases and Their Glycoprotein Substrates
O-glycosylation of proteins in Neisseria meningitidis is catalyzed by PglL, which belongs to a protein family including WaaL O-antigen ligases. We developed two hidden Markov models that identify 31Expand
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  • Open Access
Dual Pili Post-translational Modifications Synergize to Mediate Meningococcal Adherence to Platelet Activating Factor Receptor on Human Airway Cells
Pili of pathogenic Neisseria are major virulence factors associated with adhesion, twitching motility, auto-aggregation, and DNA transformation. Pili of N. meningitidis are subject to severalExpand
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  • Open Access