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Differential over‐expression of mdr1 genes in multidrug‐resistant rat glioblastoma cell lines selected with doxorubicin or vincristine
We have compared the pharmacological and molecular characteristics of 2 cell lines derived from the C6 rat glioblastoma, and selected for resistance either to doxorubicin (C6 0.5 line) or toExpand
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Genetic polymorphisms of the XPG and XPD nucleotide excision repair genes in sarcoma patients
There are more than 50 subtypes of soft tissue sarcomas, among which 30% are associated with specific genetic alterations, including translocations. Several studies have reported associations betweenExpand
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Doxorubicin-induced alterations of c-myc and c-jun gene expression in rat glioblastoma cells: role of c-jun in drug resistance and cell death.
We studied the effect of doxorubicin on the expression of c-myc and c-jun in the rat glioblastoma cell line C6 and its doxorubicin-resistant variant C6 0.5, at equitoxic exposures. For quantitation,Expand
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La réparation de l’ADN, cible potentielle d’un développement thérapeutique en cancérologie
Les mecanismes de reparation de l’ADN jouent un role crucial dans la preservation de l’integrite du genome. Ils permettent egalement de lutter contre les dommages de l’ADN induits par une grandeExpand
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Effects of modulators of multidrug resistance on the expression of the MDR1 gene in human KB cells in culture
The effect of four modulators of multidrug resistance (MDR) on the expression of the MDR1 gene was studied in two resistant variants of the KB cell lines, KB V1 and KB A1. This was done using aExpand
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Transcriptional down‐regulation of c-myc expression in an erythroleukemic cell line, K562, and its doxorubicin‐resistant variant by two topoisomerase II inhibitors, doxorubicin and amsacrine
We have evaluated the effect of two topoisomerase II (Topo II) poisons, amsacrine and doxorubicin, on the expression of the c-myc oncogene, both at the mRNA and protein levels, in the leukemia cellExpand
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Deciphering the role of the ERCC2 gene polymorphism on anticancer drug sensitivity.
ERCC2 [Xeroderma pigmentosum (XP) group D] belongs to the nucleotide excision repair pathway. It is also part of the TFIIH transcription complex and is required for the association of theExpand
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The Polyphenolic Ellagitannin Vescalagin Acts As a Preferential Catalytic Inhibitor of the α Isoform of Human DNA Topoisomerase II
Polyphenolic ellagitannins are natural compounds that are often associated with the therapeutic activity of plant extracts used in traditional medicine. They display cancer-preventing activity inExpand
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[Expression of the MDR1 gene in five human cell lines of medullary thyroid cancer and reversion of the resistance to doxorubicine by ciclosporin A and verapamil].
Medullary thyroid carcinoma (MTC) is frequently resistant to chemotherapy. Multidrug resistance (MDR) is one of the involved mechanisms. In this work we have studied the MDR1 gene expression in fiveExpand
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