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The IASLC Lung Cancer Staging Project: Proposals for the Revision of the TNM Stage Groupings in the Forthcoming (Seventh) Edition of the TNM Classification of Malignant Tumours
TLDR
Suggestions include additional cutoffs for tumor size, with tumors >7 cm moving from T2 to T3; reassigning the category given to additional pulmonary nodules in some locations; and reclassifying pleural effusion as an M descriptor. Expand
Prognostic value of right ventricular mass, volume, and function in idiopathic pulmonary arterial hypertension.
TLDR
The RV contains prognostic information in IPAH and a large RV volume, low SV, and a reduced LV volume are strong independent predictors of mortality and treatment failure. Expand
Prognostic factors in patients with pleural mesothelioma: the European Organization for Research and Treatment of Cancer experience.
TLDR
Identification of prognostic factors in patients with malignant pleural mesothelioma based on prospectively collected international data may help to design new clinical trials in pleural Mesot Helioma by selecting more homogenous groups of patients. Expand
Prophylactic cranial irradiation in extensive small-cell lung cancer.
TLDR
Prophylactic cranial irradiation reduces the incidence of symptomatic brain metastases and prolongs disease-free and overall survival and did not have a clinically significant effect on global health status. Expand
The IASLC Lung Cancer Staging Project: Proposals for Revision of the M Descriptors in the Forthcoming (Seventh) Edition of the TNM Classification of Lung Cancer
TLDR
Revisions to the TNM classification system for lung cancer should include grouping cases with malignant pleural effusions and cases with nodules in the contralateral lung in the M1a category, and casesWith distant metastases should be designated M1b. Expand
Effectiveness of positron emission tomography in the preoperative assessment of patients with suspected non-small-cell lung cancer: the PLUS multicentre randomised trial
TLDR
Addition of PET to conventional workup prevented unnecessary surgery in one out of five patients with suspected non-small-cell lung cancer, and the primary outcome measure was futile thoracotomy. Expand
Right Ventricular Diastolic Impairment in Patients With Pulmonary Arterial Hypertension
TLDR
RV diastolic stiffness is significantly increased in PAH patients, with important contributions from increased collagen and intrinsic stiffening of the RV cardiomyocyte sarcomeres and titin phosphorylation. Expand
Dysregulated renin-angiotensin-aldosterone system contributes to pulmonary arterial hypertension.
TLDR
Systemic and pulmonary RAAS activities are increased in patients with iPAH and are associated with increased pulmonary vascular remodeling and chronic inhibition of RAAS by losartan is beneficial in experimental PAH. Expand
Noninvasively assessed pulmonary artery stiffness predicts mortality in pulmonary arterial hypertension.
TLDR
Noninvasively measured pulmonary artery RAC predicted mortality better than area distensibility in patients with PAH, and showed an inverse curvilinear relation with mean pulmonary artery pressure. Expand
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