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Mechanisms of hypersensitivity in IBS and functional disorders
General introduction  The concept of visceral hypersensitivity is accepted as being germane to several functional gastrointestinal disorders (FGIDs). The causes or risk factors associated with thisExpand
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Gastric inhibitory polypeptide-dependent cortisol hypersecretion--a new cause of Cushing's syndrome.
BACKGROUND Corticotropin-independent nodular adrenal hyperplasia is a rare cause of Cushing's syndrome, and the factors responsible for the adrenal hyperplasia are not known. METHODS We studied aExpand
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Expression of Key Prostaglandin Synthases in Equine Endometrium During Late Diestrus and Early Pregnancy1
Abstract Luteolysis in domestic species is mediated by the release of luteolytic pulses of prostaglandin (PG) F2α by the uterus at the end of diestrus, which must be suppressed by the conceptus toExpand
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Rectal distention testing in patients with irritable bowel syndrome: sensitivity, specificity, and predictive values of pain sensory thresholds.
BACKGROUND & AIMS Visceral hypersensitivity was detected in patients with functional gastrointestinal disorders and has been proposed as a biological marker of irritable bowel syndrome (IBS). TheExpand
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Thicker posterior insula is associated with disease duration in women with irritable bowel syndrome (IBS) whereas thicker orbitofrontal cortex predicts reduced pain inhibition in both IBS patients
UNLABELLED Patients with irritable bowel syndrome (IBS) are affected by chronic abdominal pain and show decreased pain inhibition. Moreover, they exhibit differences in brain morphology compared withExpand
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Widespread hypersensitivity is related to altered pain inhibition processes in irritable bowel syndrome
&NA; The mechanisms of chronic pain in irritable bowel syndrome (IBS) have been widely investigated but remain unclear. The present study investigated the relation between visceral hypersensitivity,Expand
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Biologics in inflammatory bowel disease: what are the data?
Background Over the last decade, biologics have gained an important place for the treatment of moderate to severe inflammatory bowel disease (IBD), and many randomized control trials have evaluatedExpand
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Recommendations on chronic constipation (including constipation associated with irritable bowel syndrome) treatment.
While chronic constipation (CC) has a high prevalence in primary care, there are no existing treatment recommendations to guide health care professionals. To address this, a consensus group of 10Expand
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Decreased pain inhibition in irritable bowel syndrome depends on altered descending modulation and higher-order brain processes
Irritable bowel syndrome (IBS) is a functional gastrointestinal disorder involving abdominal pain and bowel dysfunction. IBS pain symptoms have been hypothesized to depend on peripheral and centralExpand
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Irritable bowel syndrome: an international study of symptoms in eight countries
Objectives This report is a preliminary comparative study of irritable bowel syndrome symptoms in eight countries, USA, Mexico, Canada, England, Italy, Israel, India, and China. We also assessedExpand
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