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Maternal care, hippocampal glucocorticoid receptors, and hypothalamic-pituitary-adrenal responses to stress.
Variations in maternal care affect the development of individual differences in neuroendocrine responses to stress in rats. As adults, the offspring of mothers that exhibited more licking andExpand
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Early, postnatal experience alters hypothalamic corticotropin-releasing factor (CRF) mRNA, median eminence CRF content and stress-induced release in adult rats.
Rat pups 2-14 days of age were exposed daily to handling (15 min of separation from mother and home cage), maternal separation (MS; 180 min of comparable separation), or were left entirelyExpand
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Maternal care during infancy regulates the development of neural systems mediating the expression of fearfulness in the rat.
The mothers of infant rats show individual differences in the frequency of licking/grooming and arched-back nursing (LG-ABN) of pups that contribute to the development of individual differences inExpand
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Early adverse experience as a developmental risk factor for later psychopathology: evidence from rodent and primate models.
Increasing evidence supports the view that the interaction of perinatal exposure to adversity with individual genetic liabilities may increase an individual's vulnerability to the expression ofExpand
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The role of corticotropin-releasing factor in depression and anxiety disorders.
Corticotropin-releasing factor (CRF), a 41 amino acid-containing peptide, appears to mediate not only the endocrine but also the autonomic and behavioral responses to stress. Stress, in particularExpand
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The Effects of Early Rearing Environment on the Development of GABAA and Central Benzodiazepine Receptor Levels and Novelty-Induced Fearfulness in the Rat
We compared the effects of handling or maternal separation from the day following birth until postnatal day 14 on behavioral responses to novelty and on GABAA and central benzodiazepine (CBZ)Expand
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Development of adult ethanol preference and anxiety as a consequence of neonatal maternal separation in Long Evans rats and reversal with antidepressant treatment
Abstract. Rationale: This study was based on the findings of a high comorbidity among anxiety and depression as well as with alcohol abuse. Objective: To evaluate first exposure alcohol preference inExpand
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International Union of Pharmacology. XXXVI. Current Status of the Nomenclature for Receptors for Corticotropin-Releasing Factor and Their Ligands
Receptors for corticotropin-releasing factor (CRF) are members of a family of G protein-coupled receptors (“Family B”) that respond to a variety of structurally dissimilar releasing factors,Expand
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Long-term behavioral and neuroendocrine adaptations to adverse early experience.
Adaptation of an organism to the environment occurs through numerous processes beginning in the prenatal period and continuing through the neonatal and early adolescent period. Environmental signals,Expand
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Early environmental regulation of forebrain glucocorticoid receptor gene expression: implications for adrenocortical responses to stress.
The adrenal glucocorticoids and catecholamines comprise a frontline of defense for mammalian species under conditions which threaten homeostasis (conditions commonly referred to as stress).Expand
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