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New chondrosarcoma cell lines and mouse models to study the link between chondrogenesis and chemoresistance
TLDR
The results indicate that the cartilaginous matrix produced by chondrosarcoma cells may impair diffusion of several drugs and thus contribute to chemoresistance, and 3D chondrogenic cell pellets constitute a more relevant model to study chondosarcomas chemores resistance and may be a valuable alternative to animal experimentations.
BAK1 gene variation and abdominal aortic aneurysms—results may have been prematurely overrated
TLDR
It is astounding that the authors forgot to mention this crucial observation in their original article, because it runs counter to the theory of a genome varying according to the tissue, that is, the very message widely spread by the media.
Immunohistochemical localization of type IV collagen and laminin (alpha1) in denture stomatitis.
TLDR
Findings suggest a relationship between the expression of laminin (alpha1) and type IV collagen and the development of denture stomatitis, a disorder involving modification of soft tissues in which initial inflammation of the palatal mucosa results from stress under the denture.
Effects of bistramide A on a non-small-cell bronchial carcinoma line
TLDR
Bistramide A has a dual mechanism that induces blockade in the G1 phase and causes polyploidy that is suggestive of inaptitude for cytokinesis and these effects confirm the results of cytomorphology studies in electron microscopy.
Comparison of Tumor- and Bone Marrow-Derived Mesenchymal Stromal/Stem Cells from Patients with High-Grade Osteosarcoma
TLDR
Three out of seven OSDC showed a supportive role on local tumor development, and on metastatic progression to the lungs, respectively, when co-injected with OS cells in nude mice, and with the capacity to sustain tumor progression may have implications for future tumor treatments.
Chromosomal instability by mutations in the novel minor spliceosome component CENATAC
TLDR
It is shown that CENATAC is a novel component of the minor (U12‐dependent) spliceosome that promotes splicing of a specific, rare minor intron subtype, which is characterized by AT‐AN splice sites and relatively high basal levels of intron retention.
Ultrastructural and cytochemical analysis of Na+, K+, ATPase and H+, K+, ATPase in parietal cells of gastric mucosa in the rabbit
TLDR
The signs of functional alternation found in this study are in agreement with physiological data relative to this animal and suggest that proton transport ceases completely in certain cells.
Constitutional telomeric association (Y;7) in a patient with a female phenotype
TLDR
The cytogenetic and molecular analyses of a TA involving chromosomes Y and 7 in a child with a female phenotype and SNP array analysis excluded an uniparental isodisomy of chromosome 7.
Chromosomal instability by mutations in a novel specificity factor of the minor spliceosome
TLDR
It is shown that CENATAC is a novel component of the minor (U12-dependent) spliceosome that promotes splicing of a specific, rare minor intron subtype, characterized by AT-AN splice sites and relatively high basal levels of intron retention.
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