• Publications
  • Influence
Final results of a randomized phase III trial of sequential high-dose methotrexate, fluorouracil, and doxorubicin versus etoposide, leucovorin, and fluorouracil versus infusional fluorouracil and
PURPOSE To compare the efficacy and tolerability of etoposide, leucovorin, and bolus fluorouracil (ELF) or infusional fluorouracil plus cisplatin (FUP) with that of the reference protocol ofExpand
  • 515
  • 19
Multicenter randomized trial of adjuvant fluorouracil and folinic acid compared with surgery alone after resection of colorectal liver metastases: FFCD ACHBTH AURC 9002 trial.
PURPOSE Complete resection of liver metastases of colorectal origin is the only potentially curative treatment. In order to decrease recurrences, the use of adjuvant systemic chemotherapy after liverExpand
  • 468
  • 17
Progression-free survival is a surrogate for survival in advanced colorectal cancer.
PURPOSE The traditional end point for assessing efficacy of first-line chemotherapies for advanced cancer is overall survival (OS), but this end point requires prolonged follow-up and is potentiallyExpand
  • 303
  • 7
Semimonthly versus monthly regimen of fluorouracil and leucovorin administered for 24 or 36 weeks as adjuvant therapy in stage II and III colon cancer: results of a randomized trial.
PURPOSE This randomized, 2 x 2 factorial study compared a semimonthly (LVFU2) with a monthly (FULV) regimen of fluorouracil and leucovorin and 24 versus 36 weeks of each regimen as adjuvant treatmentExpand
  • 231
  • 7
Modulation of fluorouracil by leucovorin in patients with advanced colorectal cancer: an updated meta-analysis.
PURPOSE The modulation of fluorouracil (FU) by folinic acid (leucovorin [LV]) has been shown to be effective in terms of tumor response rate in patients with advanced colorectal cancer, but aExpand
  • 353
  • 5
Efficacy of intravenous continuous infusion of fluorouracil compared with bolus administration in advanced colorectal cancer.
PURPOSE The administration of fluorouracil (5-FU) by continuous intravenous infusion (CI) is an alternative to the bolus administration of 5-FU in patients with advanced colorectal cancer. AlthoughExpand
  • 940
  • 4
Detection and monitoring of serum p53 antibodies in patients with colorectal cancer.
BACKGROUND: Detection of p53 antibodies in serum might be an effective indirect procedure to detect alterations of the p53 gene. AIMS: To assess the prevalence and the variation under treatment ofExpand
  • 87
  • 4
Meta-analysis when only the median survival times are known: a comparison with individual patient data results.
BACKGROUND The hazard ratio (HR) is the most appropriate measure for time to event outcomes such as survival. In systematic reviews, HRs can be calculated either from the raw trial data obtained asExpand
  • 118
  • 4
Modulation of fluorouracil by leucovorin in patients with advanced colorectal cancer: evidence in terms of response rate. Advanced Colorectal Cancer Meta-Analysis Project.
  • P. Piedbois
  • Medicine
  • Journal of clinical oncology : official journal…
  • 1992
PURPOSE A meta-analysis was performed on nine randomized clinical trials that compared fluorouracil (5-FU) with 5-FU plus intravenous (IV) leucovorin (LV) for the treatment of advanced colorectalExpand
  • 1,169
  • 3
Intrahepatic cholangiocarcinoma. Results of aggressive surgical management.
OBJECTIVE To report the results of a deliberately aggressive surgical management in patients with intrahepatic cholangiocarcinoma. DESIGN A case series of patients with intrahepaticExpand
  • 109
  • 3