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The Impact of Sampling Schemes on the Site Frequency Spectrum in Nonequilibrium Subdivided Populations
Using coalescent simulations, we study the impact of three different sampling schemes on patterns of neutral diversity in structured populations. Specifically, we are interested in two summaryExpand
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mlRho – a program for estimating the population mutation and recombination rates from shotgun‐sequenced diploid genomes
Improvements in sequencing technology over the past 5 years are leading to routine application of shotgun sequencing in the fields of ecology and evolution. However, the theory to estimateExpand
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Convergence in distribution of random metric measure spaces (Λ-coalescent measure trees)
We consider the space of complete and separable metric spaces which are equipped with a probability measure. A notion of convergence is given based on the philosophy that a sequence of metric measureExpand
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An approximate sampling formula under genetic hitchhiking
For a genetic locus carrying a strongly beneficial allele which has just fixed in a large population, we study the ancestry at a linked neutral locus. During this ``selective sweep'' the linkageExpand
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andi: Fast and accurate estimation of evolutionary distances between closely related genomes
MOTIVATION A standard approach to classifying sets of genomes is to calculate their pairwise distances. This is difficult for large samples. We have therefore developed an algorithm for rapidlyExpand
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Tree-valued Fleming–Viot dynamics with mutation and selection
The Fleming-Viot measure-valued diffusion is a Markov process describing the evolution of (allelic) types under mutation, selection and random reproduction. We enrich this process by genealogicalExpand
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Marked metric measure spaces
A marked metric measure space (mmm-space) is a triple $(X,r,μ)$, where $(X,r)$ is a complete and separable metric space and $μ$ is a probability measure on $X \times I$ for some Polish space $I$ ofExpand
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Estimating Mutation Distances from Unaligned Genomes
Abstract Alignment-free distance measures are generally less accurate but more efficient than traditional alignment-based metrics. In the context of genome sequence analysis, the efficiency gain isExpand
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How often does the ratchet click? Facts, heuristics, asymptotics
The evolutionary force of recombination is lacking in asexually reproducing populations. As a consequence, the population can su! er an irreversible accumulation of deleterious mutations, aExpand
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Selective sweeps for recessive alleles and for other modes of dominance
A selective sweep describes the reduction of linked genetic variation due to strong positive selection. If s is the fitness advantage of a homozygote for the beneficial allele and h its dominanceExpand
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