# P. Pfaffelhuber

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- Publications
- Influence

The Impact of Sampling Schemes on the Site Frequency Spectrum in Nonequilibrium Subdivided Populations

- T. Städler, B. Haubold, C. Merino, W. Stephan, P. Pfaffelhuber
- Medicine, Biology
- Genetics
- 1 May 2009

Using coalescent simulations, we study the impact of three different sampling schemes on patterns of neutral diversity in structured populations. Specifically, we are interested in two summary… Expand

mlRho – a program for estimating the population mutation and recombination rates from shotgun‐sequenced diploid genomes

- B. Haubold, P. Pfaffelhuber, M. Lynch
- Medicine, Biology
- Molecular ecology
- 10 February 2010

Improvements in sequencing technology over the past 5 years are leading to routine application of shotgun sequencing in the fields of ecology and evolution. However, the theory to estimate… Expand

Convergence in distribution of random metric measure spaces (Λ-coalescent measure trees)

- A. Greven, P. Pfaffelhuber, A. Winter
- Mathematics
- 1 September 2009

We consider the space of complete and separable metric spaces which are equipped with a probability measure. A notion of convergence is given based on the philosophy that a sequence of metric measure… Expand

An approximate sampling formula under genetic hitchhiking

- A. Etheridge, P. Pfaffelhuber, A. Wakolbinger
- Mathematics, Biology
- 23 March 2005

For a genetic locus carrying a strongly beneficial allele which has just fixed in a large population, we study the ancestry at a linked neutral locus. During this ``selective sweep'' the linkage… Expand

andi: Fast and accurate estimation of evolutionary distances between closely related genomes

- B. Haubold, Fabian Klötzl, P. Pfaffelhuber
- Medicine, Computer Science
- Bioinform.
- 15 April 2015

MOTIVATION
A standard approach to classifying sets of genomes is to calculate their pairwise distances. This is difficult for large samples. We have therefore developed an algorithm for rapidly… Expand

Tree-valued Fleming–Viot dynamics with mutation and selection

- A. Depperschmidt, A. Greven, P. Pfaffelhuber
- Mathematics
- 4 January 2011

The Fleming-Viot measure-valued diffusion is a Markov process describing the evolution of (allelic) types under mutation, selection and random reproduction. We enrich this process by genealogical… Expand

Marked metric measure spaces

- A. Depperschmidt, A. Greven, P. Pfaffelhuber
- Mathematics
- 21 January 2011

A marked metric measure space (mmm-space) is a triple $(X,r,μ)$, where $(X,r)$ is a complete and separable metric space and $μ$ is a probability measure on $X \times I$ for some Polish space $I$ of… Expand

Estimating Mutation Distances from Unaligned Genomes

- B. Haubold, P. Pfaffelhuber, Mirjana Domazet-Lošo, T. Wiehe
- Computer Science, Medicine
- J. Comput. Biol.
- 5 October 2009

Abstract Alignment-free distance measures are generally less accurate but more efficient than traditional alignment-based metrics. In the context of genome sequence analysis, the efficiency gain is… Expand

How often does the ratchet click? Facts, heuristics, asymptotics

- A. Etheridge, P. Pfaffelhuber, A. Wakolbinger
- Mathematics, Biology
- 18 September 2007

The evolutionary force of recombination is lacking in asexually reproducing populations. As a consequence, the population can su! er an irreversible accumulation of deleterious mutations, a… Expand

Selective sweeps for recessive alleles and for other modes of dominance

- G. Ewing, J. Hermisson, P. Pfaffelhuber, J. Rudolf
- Biology, Mathematics
- Journal of mathematical biology
- 30 May 2010

A selective sweep describes the reduction of linked genetic variation due to strong positive selection. If s is the fitness advantage of a homozygote for the beneficial allele and h its dominance… Expand