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Pharmacokinetics and pharmacodynamics of the endothelin‐receptor antagonist bosentan in healthy human subjects
- C. Weber, R. Schmitt, +5 authors Charles‐Richard Jones
- Clinical pharmacology and therapeutics
- 1 August 1996
Bosentan (Ro 47‐0203) is a potent and mixed ETA‐ and ETB‐receptor antagonist. Its activity has been studied in a variety of preclinical disease models.
Absorption, Metabolism, and Excretion of Intravenously and Orally Administered [14C]Telmisartan in Healthy Volunteers
- J. Stangier, J. Schmid, +7 authors J. Jonkman
- Chemistry, Medicine
- Journal of clinical pharmacology
- 1 December 2000
The study was conducted in healthy male volunteers to evaluate the absorption, metabolic pattern, and mode of elimination of telmisartan, a nonpeptide angiotensin II receptor antagonist.… Expand
Pharmacokinetic profile of nomegestrol acetate and 17β-estradiol after multiple and single dosing in healthy women.
BACKGROUND The pharmacokinetics of the monophasic oral contraceptive nomegestrol acetate (NOMAC) plus 17β-estradiol (E(2)) were investigated after a single dose and multiple dosing. STUDY DESIGN… Expand
Safety and tolerability of single intravenous doses of sugammadex administered simultaneously with rocuronium or vecuronium in healthy volunteers.
BACKGROUND Sugammadex rapidly reverses rocuronium- and vecuronium-induced neuromuscular block. To investigate the effect of combination of sugammadex and rocuronium or vecuronium on QT interval, it… Expand
Concomitant use of mirtazapine and phenytoin: a drug–drug interaction study in healthy male subjects
- E. Spaans, M. W. van den Heuvel, +4 authors J. Sitsen
- European Journal of Clinical Pharmacology
- 1 August 2000
HeadingAbstractObjective. The objectives of this study were to assess the effect of mirtazapine on steady-state pharmacokinetics of phenytoin and vice versa and to assess tolerability and safety of… Expand
A randomized controlled trial of artemotil (beta-arteether) in Zambian children with cerebral malaria.
- P. Thuma, G. Bhat, +7 authors V. Gordeuk
- The American journal of tropical medicine and…
- 1 April 2000
The efficacy and safety of intramuscular artemotil (ARTECEF) was compared to intravenous quinine in African children with cerebral malaria. This prospective block randomized open-label study was… Expand
Glycine Transporter Inhibitor Attenuates the Psychotomimetic Effects of Ketamine in Healthy Males: Preliminary Evidence
Enhancing glutamate function by stimulating the glycine site of the NMDA receptor with glycine, D-serine, or with drugs that inhibit glycine reuptake may have therapeutic potential in schizophrenia.… Expand
Residual effects of esmirtazapine on actual driving performance: overall findings and an exploratory analysis into the role of CYP2D6 phenotype
- J. Ramaekers, S. Conen, +4 authors Neely Ivgy-may
- Psychology, Medicine
- 19 January 2011
IntroductionEsmirtazapine is evaluated as a novel drug for treatment of insomnia.PurposeThe present study was designed to assess residual effects of single and repeated doses of esmirtazapine 1.5 and… Expand
Asenapine Pharmacokinetics in Hepatic and Renal Impairment
AbstractBackground and Objective: The effects of hepatic or renal impairment on the pharmacokinetics of atypical antipsychotics are not well understood. Drug exposure may increase in patients with… Expand
Repeat dosing of rocuronium 1.2 mg kg-1 after reversal of neuromuscular block by sugammadex 4.0 mg kg-1 in anaesthetized healthy volunteers: a modelling-based pilot study.
BACKGROUND Re-intubation and re-operation may occasionally be required after neuromuscular block (NMB) reversal. This study evaluated block onset times of a second dose of rocuronium (1.2 mg kg(-1))… Expand