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Identification of 23 new prostate cancer susceptibility loci using the iCOGS custom genotyping array
TLDR
On the basis of combined risks conferred by the new and previously known risk loci, the top 1% of the risk distribution has a 4.7-fold higher risk than the average of the population being profiled.
Association analyses of more than 140,000 men identify 63 new prostate cancer susceptibility loci
TLDR
A large meta-analysis combining genome-wide and custom high-density genotyping array data identifies 63 new susceptibility loci for prostate cancer, enhancing fine-mapping efforts and providing insights into the underlying biology of PrCa1.
A meta-analysis of 87,040 individuals identifies 23 new susceptibility loci for prostate cancer
TLDR
These findings provide new regions for investigation into the pathogenesis of prostate cancer and demonstrate the usefulness of combining ancestrally diverse populations to discover risk loci for disease.
FLI1 is a novel ETS transcription factor involved in gene fusions in prostate cancer
TLDR
It is reported that FLI1 is a novel ETS transcription factor involved in gene fusions in prostate cancer and that intratumor genetic heterogeneity of ETS rearrangements can occasionally be found in index primary tumors.
Cysteine-Rich Secretory Protein-3 (CRISP3) Is Strongly Up-Regulated in Prostate Carcinomas with the TMPRSS2-ERG Fusion Gene
TLDR
It is shown that CRISP3 is a direct target of ERG that is strongly overexpressed in PCa with the TMPRSS2-ERG fusion gene and is associated with significant expression alterations in genes involved in critical cellular pathways that define a subset of locally advanced PCa.
Implementation of next-generation sequencing for molecular diagnosis of hereditary breast and ovarian cancer highlights its genetic heterogeneity
TLDR
Next-generation sequencing is validated for the detection of BRCA1/BRCA2 point mutations in a diagnostic setting and the role of other genes associated with HBOC in Portuguese families is studied to highlight the genetic heterogeneity of HBOC.
Polygenic hazard score to guide screening for aggressive prostate cancer: development and validation in large scale cohorts
TLDR
Polygenic hazard scores can be used for personalised genetic risk estimates that can predict for age at onset of aggressive PCa in men participating in international PRACTICAL consortium.
Fine-mapping of prostate cancer susceptibility loci in a large meta-analysis identifies candidate causal variants
TLDR
The authors perform multivariate fine-mapping of known PrCa GWAS loci, identifying variants enriched for biological function, explaining more familial relative risk, and with potential application in clinical risk profiling.
Novel 5' fusion partners of ETV1 and ETV4 in prostate cancer.
TLDR
It is indicated that all genes described as 5' fusion partners with one ETS gene can most likely be rearranged with any of the other ETS genes involved in prostate carcinogenesis.
Key elements of the BMP/SMAD pathway co‐localize with CDX2 in intestinal metaplasia and regulate CDX2 expression in human gastric cell lines
TLDR
It is identified for the first time that the BMP pathway is active in intestinal metaplasia and that BMP2 and BMP4 regulate CDX2 expression and promote intestinal differentiation through the canonical signal transducers.
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