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Paralog-selective Hsp90 inhibitors define tumor-specific regulation of HER2.
Although the Hsp90 chaperone family, comprised in humans of four paralogs, Hsp90α, Hsp90β, Grp94 and Trap-1, has important roles in malignancy, the contribution of each paralog to the cancerExpand
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Selective targeting of the stress chaperome as a therapeutic strategy.
Normal cellular function is maintained by coordinated proteome machinery that performs a vast array of activities. Helping the proteome in such roles is the chaperome, a network of molecularExpand
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Identification of an allosteric pocket on human hsp70 reveals a mode of inhibition of this therapeutically important protein.
Hsp70s are important cancer chaperones that act upstream of Hsp90 and exhibit independent anti-apoptotic activities. To develop chemical tools for the study of human Hsp70, we developed a homologyExpand
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Retrospective study of Fine Needle Aspiration Cytology of thyroid lesions according to The Bethesda System for Reporting Thyroid Cytopathology ( TBSRTC )
BACKGROUND & Objectives: Fine needle aspiration cytology (FNAC) plays important role in diagnosis of thyroid lesions. However conventional reporting of cytology lack standardize format. To overcomeExpand
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3D QSAR and Molecular Docking Studies of Benzimidazole Derivatives as Hepatitis C Virus NS5B Polymerase Inhibitors
The urgent need for novel HCV antiviral agents has provided an impetus for understanding the structural requisites of NS5B polymerase inhibitors at the molecular level. Toward this objective,Expand
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Structure-activity relationship in a purine-scaffold compound series with selectivity for the endoplasmic reticulum Hsp90 paralog Grp94.
Grp94 is involved in the regulation of a restricted number of proteins and represents a potential target in a host of diseases, including cancer, septic shock, autoimmune diseases, chronicExpand
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Design, synthesis and determination of antifungal activity of 5(6)-substituted benzotriazoles.
In an effort to find inhibitors that are effective against both Candida and Aspergillus spp., a series of 5(6)-(un)substituted benzotriazole analogs, represented by compounds 3a-3h and 3b'-3f', wereExpand
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The effects and effectiveness of electromotive drug administration and chemohyperthermia for treating non-muscle invasive bladder cancer.
INTRODUCTION Preliminary studies show that device assisted intravesical therapies appear more effective than passive diffusion intravesical therapy for the treatment of non-muscle invasive bladderExpand
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Paralog-selective Hsp 90 inhibitors define tumor-specific regulation of Her 2
Although the Hsp90 chaperone family, comprised in humans of four paralogs, Hsp90α, Hsp90β, Grp94 and Trap-1, has important roles in malignancy, the contribution of each paralog to the cancerExpand
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Study of functional outcomes of surgical treatment of tuberculosis of spine with debridement and spinal fixation
Background: Spinal tubercular infection is the most common and dangerous form of skeletal tuberculosis. It constitutes 1/3 to 1/2 of all bone and joint tuberculosis. Even today tb spine is a lifeExpand
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