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Isolation and characterization of an adipokinetic hormone release-inducing factor in locusts: the crustacean cardioactive peptide.
The present study shows that synthetic crustacean cardioactive peptide induces the release of AKH from corpora cardiaca in a dose-dependent manner when tested in concentrations ranging from 10(-5)-10(-9) M.
Sugammadex is cleared rapidly and primarily unchanged via renal excretion
This single‐center, open‐label, non‐randomized study used 14C‐labeled sugammadex to further investigate the excretion, metabolic and pharmacokinetic (PK) profiles of sugamadex in six healthy male volunteers.
A novel approach to identify responder subgroups and predictors of response to low‐ and high‐dose capsaicin patches in postherpetic neuralgia
An alternative approach is the identification of specific patient subgroups characterized by differential response patterns in their analgesic response and to determine the presence of significant predictors of effect.
Safety, tolerability and pharmacokinetics of sugammadex using single high doses (up to 96 mg/kg) in healthy adult subjects: a randomized, double-blind, crossover, placebo-controlled, single-centre
Sugammadex was well tolerated in 12 of the 13 subjects, with adverse events being generally mild, of limited duration and more frequent at higher doses, and pharmacokinetics were dose linear over the range 32-96 mg/kg, with elimination predominantly via the renal route.
Trehalose inhibits the release of adipokinetic hormones from the corpus cardiacum in the African migratory locust, Locusta migratoria, at the level of the adipokinetic cells.
The hypothesis that in vivo the relatively high concentration of trehalose (80 mM) at rest strongly inhibits the release of AKHs is supported, because at the onset of flight, the demand for energy substrates exceeds the amount oftrehalose that can be mobilized from the fat body and consequently the treHalose concentration in the hemolymph decreases.
A possible role of Schisto FLRFamide in inhibition of adipokinetic hormone release from locust corpora cardiaca
Results point to an involvement of FaRPs as inhibitory modulators in the regulation of the release of adipokinetic hormone from the glandular cells.
Modulatory effects of biogenic amines on adipokinetic hormone secretion from locust corpora cardiaca in vitro.
The control of the release of adipokinetic hormones from neurosecretory cells within the glandular lobes of the corpus cardiacum involving axons running through the paired nervus corporis cardiaci II
Several isoforms of locustatachykinins may be involved in cyclic AMP-mediated release of adipokinetic hormones from the locust Corpora cardiaca.
Results support the proposal that LomTKs are involved in controlling the release of the adipokinetic hormones and suggest that all LOMTK isoforms may participate in this cyclic AMP-mediated event.
Safety, Tolerability and Pharmacokinetics of Sugammadex Using Single High Doses (Up to 96 mg/kg) in Healthy Adult Subjects
High doses of sugammadex (up to 96 mg/kg) were well tolerated in 12 of the 13 subjects, with adverse events being generally mild, of limited duration and more frequent at higher doses.