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A new model of chronic visceral hypersensitivity in adult rats induced by colon irritation during postnatal development.
BACKGROUND & AIMS The irritable bowel syndrome (IBS) is a common disorder characterized by abdominal pain in the setting of altered perception of viscerosensory stimuli. This so-called visceral… Expand
Ano1 is a selective marker of interstitial cells of Cajal in the human and mouse gastrointestinal tract.
- P. Gomez-Pinilla, S. J. Gibbons, +12 authors G. Farrugia
- Biology, Medicine
- American journal of physiology. Gastrointestinal…
- 1 June 2009
Populations of interstitial cells of Cajal (ICC) are altered in several gastrointestinal neuromuscular disorders. ICC are identified typically by ultrastructure and expression of Kit (CD117), a… Expand
Identification of a cKit(+) colonic crypt base secretory cell that supports Lgr5(+) stem cells in mice.
- M. E. Rothenberg, Ysbrand M. Nusse, +11 authors M. Clarke
- Biology, Medicine
- 1 May 2012
BACKGROUND & AIMS Paneth cells contribute to the small intestinal niche of Lgr5(+) stem cells. Although the colon also contains Lgr5(+) stem cells, it does not contain Paneth cells. We investigated… Expand
DCLK1 marks a morphologically distinct subpopulation of cells with stem cell properties in preinvasive pancreatic cancer.
BACKGROUND & AIMS As in other tumor types, progression of pancreatic cancer may require a functionally unique population of cancer stem cells. Although such cells have been identified in many… Expand
Nerve growth factor regulates VR-1 mRNA levels in cultures of adult dorsal root ganglion neurons
&NA; Nerve growth factor (NGF) regulates the nociceptive properties including sensitivity to capsaicin of a subset of dorsal root ganglion neurons, which express the high‐affinity NGF receptor, trkA.… Expand
Inhibition of apoptosis during development of colorectal cancer.
Colorectal tumorigenesis proceeds through an accumulation of specific genetic alterations. Studies of the mechanism by which these genetic changes effect malignant transformation have focused on the… Expand
The Proteinase-Activated Receptor 2 Is Involved in Nociception
- W. Hoogerwerf, L. Zou, +6 authors P. Pasricha
- Medicine, Biology
- The Journal of Neuroscience
- 15 November 2001
The proteinase-activated receptor 2 is expressed on a subset of primary afferent neurons and may participate in the neurogenic component of inflammation. We hypothesized that this receptor may also… Expand
Gastroparesis and functional dyspepsia: excerpts from the AGA/ANMS meeting
- H. Parkman, M. Camilleri, +22 authors F. Hamilton
- Neurogastroenterology and motility : the official…
- 1 February 2010
Background Despite the relatively high prevelance of gastroparesis and functional dyspepsia, the aetiology and pathophysiology of these disorders remain incompletely understood. Similarly, the… Expand
Intrasphincteric botulinum toxin for the treatment of achalasia.
- P. Pasricha, W. Ravich, T. Hendrix, S. Sostre, B. Jones, A. Kalloo
- The New England journal of medicine
- 23 March 1995
BACKGROUND Achalasia is a disorder of swallowing in which the lower esophageal sphincter fails to relax. We report the use of botulinum toxin, a paralytic agent, for the treatment of this condition.… Expand
The vanilloid receptor initiates and maintains colonic hypersensitivity induced by neonatal colon irritation in rats.
- J. Winston, M. Shenoy, D. Medley, A. Naniwadekar, P. Pasricha
- 1 February 2007
BACKGROUND & AIMS Robust chemical or mechanical irritation of the colon of neonatal rats leads to chronic visceral hypersensitivity. The clinical and physiologic relevance of such noxious stimulation… Expand