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A new model of chronic visceral hypersensitivity in adult rats induced by colon irritation during postnatal development.
BACKGROUND & AIMS The irritable bowel syndrome (IBS) is a common disorder characterized by abdominal pain in the setting of altered perception of viscerosensory stimuli. This so-called visceralExpand
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Ano1 is a selective marker of interstitial cells of Cajal in the human and mouse gastrointestinal tract.
Populations of interstitial cells of Cajal (ICC) are altered in several gastrointestinal neuromuscular disorders. ICC are identified typically by ultrastructure and expression of Kit (CD117), aExpand
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Identification of a cKit(+) colonic crypt base secretory cell that supports Lgr5(+) stem cells in mice.
BACKGROUND & AIMS Paneth cells contribute to the small intestinal niche of Lgr5(+) stem cells. Although the colon also contains Lgr5(+) stem cells, it does not contain Paneth cells. We investigatedExpand
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DCLK1 marks a morphologically distinct subpopulation of cells with stem cell properties in preinvasive pancreatic cancer.
BACKGROUND & AIMS As in other tumor types, progression of pancreatic cancer may require a functionally unique population of cancer stem cells. Although such cells have been identified in manyExpand
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Inhibition of apoptosis during development of colorectal cancer.
Colorectal tumorigenesis proceeds through an accumulation of specific genetic alterations. Studies of the mechanism by which these genetic changes effect malignant transformation have focused on theExpand
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Nerve growth factor regulates VR-1 mRNA levels in cultures of adult dorsal root ganglion neurons
&NA; Nerve growth factor (NGF) regulates the nociceptive properties including sensitivity to capsaicin of a subset of dorsal root ganglion neurons, which express the high‐affinity NGF receptor, trkA.Expand
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The Proteinase-Activated Receptor 2 Is Involved in Nociception
The proteinase-activated receptor 2 is expressed on a subset of primary afferent neurons and may participate in the neurogenic component of inflammation. We hypothesized that this receptor may alsoExpand
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Intrasphincteric botulinum toxin for the treatment of achalasia.
BACKGROUND Achalasia is a disorder of swallowing in which the lower esophageal sphincter fails to relax. We report the use of botulinum toxin, a paralytic agent, for the treatment of this condition.Expand
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Gastroparesis and functional dyspepsia: excerpts from the AGA/ANMS meeting
Background  Despite the relatively high prevelance of gastroparesis and functional dyspepsia, the aetiology and pathophysiology of these disorders remain incompletely understood. Similarly, theExpand
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The vanilloid receptor initiates and maintains colonic hypersensitivity induced by neonatal colon irritation in rats.
BACKGROUND & AIMS Robust chemical or mechanical irritation of the colon of neonatal rats leads to chronic visceral hypersensitivity. The clinical and physiologic relevance of such noxious stimulationExpand
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