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Analysis of shared heritability in common disorders of the brain
It is demonstrated that, in the general population, the personality trait neuroticism is significantly correlated with almost every psychiatric disorder and migraine, and it is shown that both psychiatric and neurological disorders have robust correlations with cognitive and personality measures.
PCA-Correlated SNPs for Structure Identification in Worldwide Human Populations
A novel algorithm is presented that is effectively used for the analysis of admixed populations without having to trace the origin of individuals, and can be easily applied on large genome-wide datasets, facilitating the identification of population substructure, stratification assessment in multi-stage whole-genome association studies, and the study of demographic history in human populations.
Estimation of genetic risk for type 1 diabetes.
PCR based typing methods that utilize blood spot samples, microtiter plate format and lanthanide labeled oligonucleotide probes to define HLA-DQ and -DR alleles relevant for T1DM risk are developed.
Interrogating the Genetic Determinants of Tourette's Syndrome and Other Tic Disorders Through Genome-Wide Association Studies.
Modulation of gene expression through noncoding variants, particularly within cortico-striatal circuits, is implicated as a fundamental mechanism in Tourette's syndrome pathogenesis, supporting the unification of Tourette’s syndrome and other tic disorders in future diagnostic schemata.
COMT haplotypes suggest P2 promoter region relevance for schizophrenia
New haplotype data support the hypothesis of a relevant cis variant linked to the rs737865 site, possibly just upstream in the P2 promoter driving transcription of the predominant form of COMT in the brain.
The distribution and most recent common ancestor of the 17q21 inversion in humans.
Tracing Sub-Structure in the European American Population with PCA-Informative Markers
A novel method that can remove redundancy from the selected SNP panels and show that it can effectively remove correlated markers is developed, thus increasing genotyping savings and significantly decreases genotyped costs.
Inferring Geographic Coordinates of Origin for Europeans Using Small Panels of Ancestry Informative Markers
A systematic exploration of the extent to which geographic coordinates of origin within Europe can be predicted, with small panels of SNPs, and proposes SNPs that can prove extremely useful in a variety of different settings, such as stratification correction or genetic ancestry testing, and the study of the history of European populations.
ENIGMA and global neuroscience: A decade of large-scale studies of the brain in health and disease across more than 40 countries
This review summarizes the last decade of work by the ENIGMA Consortium, a global alliance of over 1400 scientists across 43 countries, studying the human brain in health and disease, and highlights the advantages of collaborative large-scale coordinated data analyses for testing reproducibility and robustness of findings.