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Gonadotropin-independent regulation of steroidogenesis in the fetal rat testis.
It is found by reverse transcription-polymerase chain reaction (RT-PCR) that the LHbeta-subunit gene expression in the fetal pituitary gland starts on embryonic day (E) 16.5, indicating that pituitARY LH cannot be the initial stimulus for fetal testicular steroidogenesis.
Laparoscopic vs robotic-assisted surgery for endometrial carcinoma in a centre with long laparoscopic experience
It is concluded that robotic technology is feasible but does not provide short-term benefits for the treatment of endometrial carcinoma in a centre where laparoscopy has been established as the standardised minimally invasive surgical method.
Role of DNA Methylation and Epigenetic Silencing of HAND2 in Endometrial Cancer Development
TB filled in by Laureen Please see later in the article for the Editors' Summary
Progestin-releasing intrauterine systems.
The levonorgestrel-releasing intrauterine system (LNG IUS) is an effective method for contraception, and the risk of pelvic inflammatory disease is reduced, because of reduced menstrual blood loss, endometrial suppression, and thickening of the cervical mucus.
The effect of local intrauterine levonorgestrel administration on endometrial thickness and uterine blood circulation.
It is concluded that the inactivation process of the endometrium can be monitored by transvaginal sonography and that locally administered levonorgestrel does not change circulatory conditions detectable by Doppler flow.
Effects of levonorgestrel-releasing intra-uterine system on the expression of vascular endothelial growth factor and adrenomedullin in the endometrium in adenomyosis.
This is the first study to demonstrate that LNg-IUS insertion results in decreased expression of VEGF and increased expression of AM in the endometrial glands and stroma after 3 months of use.
The ultrastructure of human endometrium is altered by administration of intrauterine levonorgestrel.
The especially well-developed and uninterrupted basal lamina may be involved in the mechanism of the LNG IUS-induced endometrial suppression, and the complex intercellular junctions between the epithelial cells persist during the local administration of levonorgestrel.
Effects of the levonorgestrel-releasing intrauterine system on proliferation and apoptosis in the endometrium.
The increase in apoptosis associated with increased Fas antigen expression and decreased Bcl-2 protein expression in the endometrium may be one of the underlying molecular mechanisms by which LNg-IUS insertion causes the atrophic change of the endometricrium.