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Nitric oxide and peroxynitrite in health and disease.
Current evidence indicates that most of the cytotoxicity attributed to NO is rather due to peroxynitrite, produced from the diffusion-controlled reaction between NO and another free radical, the superoxide anion, which is presented in detail in this review.
The Endocannabinoid System as an Emerging Target of Pharmacotherapy
A comprehensive overview on the current state of knowledge of the endocannabinoid system as a target of pharmacotherapy is provided.
Endocannabinoid activation at hepatic CB1 receptors stimulates fatty acid synthesis and contributes to diet-induced obesity.
- D. Osei-Hyiaman, M. Depetrillo, G. Kunos
- Biology, MedicineThe Journal of clinical investigation
- 2 May 2005
It is concluded that anandamide acting at hepatic CB(1) contributes to diet-induced obesity and that the FAS pathway may be a common molecular target for central appetitive and peripheral metabolic regulation.
CD39 and CD73 in immunity and inflammation.
Adenosine receptors: therapeutic aspects for inflammatory and immune diseases
- G. Haskó, J. Linden, B. Cronstein, P. Pacher
- Biology, MedicineNature Reviews Drug Discovery
- 20 July 2006
This work has generated excitement regarding the potential use of adenosine-receptor-based therapies in the treatment of infection, autoimmunity, ischaemia and degenerative diseases.
NO-independent stimulators and activators of soluble guanylate cyclase: discovery and therapeutic potential
- O. V. Evgenov, P. Pacher, Peter M. Schmidt, G. Haskó, H. Schmidt, J. Stasch
- BiologyNature Reviews Drug Discovery
- 1 September 2006
The discovery, biochemistry, pharmacology and clinical potential of haem-dependent sGC stimulators andHaem-independent sGC activators are reviewed.
Therapeutic Effects of Xanthine Oxidase Inhibitors: Renaissance Half a Century after the Discovery of Allopurinol
A critical overview of the effects of XO inhibitors in various pathophysiological conditions is presented and the various emerging therapeutic strategies offered by this approach are reviewed.
Cannabinoids mediate analgesia largely via peripheral type 1 cannabinoid receptors in nociceptors
It is concluded that the contribution of CB1-type receptors expressed on the peripheral terminals of nociceptors to cannabinoid-induced analgesia is paramount, which should enable the development of peripherally acting CB1 analgesic agonists without any central side effects.
Measurement of cardiac function using pressure–volume conductance catheter technique in mice and rats
This method is unique for providing measures of left ventricular performance that are more specific to the heart and less affected by vascular loading conditions.
Dysregulation of the Peripheral and Adipose Tissue Endocannabinoid System in Human Abdominal Obesity
The findings suggest that abdominal fat accumulation is a critical correlate of the dysregulation of the peripheral endocannabinoid system in human obesity and may represent a primary target for the treatment of abdominal obesity and associated metabolic changes.