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New cassane butenolide hemiketal diterpenes from the marine creeper Caesalpinia bonduc and their antiproliferative activity
Two new cassane butenolides, caesalpinolide A (1) and B (2), epimeric at the hemiketal position were isolated from the marine creeper Caesalpinia bonduc. The structures were elucidated by theExpand
Antiproliferative Action of Xylopia aethiopica Fruit Extract on Human Cervical Cancer Cells
Results indicate that XAFE could be a potential therapeutic agent against cancer since it inhibits cell proliferation, and induces apoptosis and cell cycle arrest in C‐33A cells. Expand
A review on cassane and norcassane diterpenes and their pharmacological studies.
A comprehensive account of the structural diversity (322 structures, 114 references) is given in this review along with biological activities of cassane and norcassane diterpenes up to September 2011. Expand
Furanoflavonoids from Pongamia pinnata fruits.
Fruits of Pongamia pinnata afforded four new furanoflavonoids, pongapinnol A-D, and a new coumestan, pONGacoumestans, along with thirteen known compounds 6-18, which are isolated for the first time from this plant. Expand
Anti-colon cancer activity of Murraya koenigii leaves is due to constituent murrayazoline and O-methylmurrayamine A induced mTOR/AKT downregulation and mitochondrial apoptosis.
In vitro studies provided scientific basis of the use of M. koenigii leaves in the traditional Indian Ayurveda medicines, but also expands possibilities of medicinal uses of Pyranocarbazole alkaloids against colon cancer. Expand
Terminalia arjuna a sacred medicinal plant: phytochemical and pharmacological profile
The present review summarizes the ethnic use, pharmacological activities of the extracts and phytoconstituents of T. arjuna for last 90 years. Expand
Synthesis of 4-hydroxy-1-methylindole and benzo[b]thiophen-4-ol based unnatural flavonoids as new class of antimicrobial agents☆
Synthesis of nitrogen and sulfur heterocyclic mimics of furanoflavonoids have been achieved for the first time and the compound 19 was the best and showed comparable MICs to the known compound karanjin. Expand
Antileishmanial Activity of Pyrazolopyridine Derivatives and Their Potential as an Adjunct Therapy with Miltefosine.
Investigating the effect of 6j on Leishmania promastigotes revealed that it induced molecular events, such as a loss in mitochondrial membrane potential, externalization of phosphatidylserine, and DNA fragmentation, that ultimately resulted in the programmed cell death of the parasite. Expand
Regioselective α-arylation of coumarins and 2-pyridones with phenylhydrazines under transition-metal-free conditions
A facile regioselective metal-free direct α-arylation of coumarins and 2-pyridones is achieved by the reaction of coumarins and 2-pyridones with phenylhydrazine in good yields. The reaction proceedsExpand
Coagulin-L ameliorates TLR4 induced oxidative damage and immune response by regulating mitochondria and NOX-derived ROS.
Coagulin-L can be of therapeutic importance in pathological conditions induced by oxidative damage and alleviated the ROS mediated oxidative damage which was assessed through protein carbonyl, lipid hydroperoxide, 8-isoprostane and 8-hydroxy-2-deoxyguanosine quantification. Expand