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The L4 22-Kilodalton Protein Plays a Role in Packaging of the Adenovirus Genome
- P. Ostapchuk, M. E. Anderson, S. Chandrasekhar, P. Hearing
- Medicine, Biology
- Journal of Virology
- 15 July 2006
ABSTRACT Packaging of the adenovirus (Ad) genome into a capsid is absolutely dependent upon the presence of a cis-acting region located at the left end of the genome referred to as the packaging… Expand
Functional interaction of nuclear factors EF-C, HNF-4, and RXR alpha with hepatitis B virus enhancer I.
Hepatitis B virus (HBV) enhancer I contains cis-acting elements that are both sufficient and essential for liver-specific enhancer function. The EF-C binding site was previously shown to be a key… Expand
A dramatic shift in the transmembrane topology of a viral envelope glycoprotein accompanies hepatitis B viral morphogenesis.
The envelope of hepatitis B virus contains three related glycoproteins (termed L, M and S) produced by alternative translation initiation in a single coding region. The smallest of these, the S… Expand
Functional Interaction of the Adenovirus IVa2 Protein with Adenovirus Type 5 Packaging Sequences
ABSTRACT Adenovirus type 5 (Ad5) DNA packaging is initiated in a polar fashion from the left end of the genome. The packaging process is dependent on the cis-acting packaging domain located between… Expand
A core viral protein binds host nucleosomes to sequester immune danger signals
Viral proteins mimic host protein structure and function to redirect cellular processes and subvert innate defenses. Small basic proteins compact and regulate both viral and cellular DNA genomes.… Expand
Control of adenovirus packaging
The results of studies of Adenovirus have contributed to our basic understanding of the molecular biology of the cell. While a great body of knowledge has been developed concerning Ad gene… Expand
Chemoselective attachment of small molecule effector functionality to human adenoviruses facilitates gene delivery to cancer cells.
- P. Banerjee, P. Ostapchuk, P. Hearing, I. Carrico
- Medicine, Chemistry
- Journal of the American Chemical Society
- 10 September 2010
We demonstrate here a novel two-step "click" labeling process in which adenoviral particles are first metabolically labeled during production with unnatural azido sugars. Subsequent chemoselective… Expand
Binding of nuclear factor EF-C to a functional domain of the hepatitis B virus enhancer region.
Nuclear factor EF-C is present in extracts prepared from human HepG2 liver cells and from other, nonliver cell lines and binds to the hepatitis B virus and polyomavirus transcriptional enhancer… Expand
Interaction of a nuclear factor with the polyomavirus enhancer region.
- P. Ostapchuk, J. F. Diffley, J. Bruder, B. Stillman, A. J. Levine, P. Hearing
- Biology, Medicine
- Proceedings of the National Academy of Sciences…
- 1 November 1986
We have identified a factor present in nuclear extracts of undifferentiated F9 murine embryonal carcinoma cells that specifically interacts with the polyomavirus enhancer region. Nuclease "footprint"… Expand
Characterization of Empty Adenovirus Particles Assembled in the Absence of a Functional Adenovirus IVa2 Protein
ABSTRACT The molecular mechanism for packaging of the adenovirus (Ad) genome into the capsid is likely similar to that of DNA bacteriophages and herpesviruses—the insertion of viral DNA through a… Expand