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Phosphoinositide signalling links O-GlcNAc transferase to insulin resistance
It is shown that O-GlcNAc transferase (OGT) harbours a previously unrecognized type of phosphoinositide-binding domain, which underscores the contribution of this modification to the aetiology of insulin resistance and type 2 diabetes. Expand
Prolyl 4-hydroxylation regulates Argonaute 2 stability
Hydroxylation is identified as a post-translational modification important for Ago2 stability and effective RNA interference. Expand
Role of Rho-kinase in regulation of insulin action and glucose homeostasis.
It is shown that insulin stimulation of glucose transport is impaired when ROK is chemically or biologically inhibited in cultured adipocytes and myotubes and in isolated soleus muscle ex vivo. Expand
The XLMR gene PHF8 encodes a histone H4K20/H3K9 demethylase and regulates zebrafish brain and craniofacial development
Genetic and molecular evidence supports a model whereby PHF8 regulates zebrafish neuronal cell survival and jaw development in part by directly regulating the expression of the homeodomain transcription factor MSX1/MSXB, which functions downstream of multiple signalling and developmental pathways. Expand
p53 induction and activation of DDR1 kinase counteract p53‐mediated apoptosis and influence p53 regulation through a positive feedback loop
DDR1, discoidin domain receptor 1, belongs to a subfamily of tyrosine kinase receptors with an extracellular domain homologous to Dictyostellium discoideum protein discoidin 1. We showed that DDR1 isExpand
p53‐mediated induction of Cox‐2 counteracts p53‐ or genotoxic stress‐induced apoptosis
Results demonstrate that Cox‐2 is induced by p53‐mediated activation of the Ras/Raf/ERK cascade, counteracting p 53‐mediated apoptosis, and this anti‐apoptosis effect may be a mechanism to abate cellular stresses associated with p53 induction. Expand
HB-EGF Is a Potent Inducer of Tumor Growth and Angiogenesis
Findings establish s-HB-EGF as a potent inducer of tumor growth and angiogenesis and suggest that therapeutic intervention aimed at the inhibition of s- HB- EGF functions may be useful in cancer treatment. Expand
GAMT, a p53-inducible modulator of apoptosis, is critical for the adaptive response to nutrient stress.
This work identifies guanidinoacetate methyltransferase (GAMT), an enzyme involved in creatine synthesis, as a p53 target gene and a key downstream effector of adaptive response to nutrient stress, demonstrating a further role of p53 in cellular metabolism. Expand
Inositol hexakisphosphate in Schizosaccharomyces pombe: synthesis from Ins(1,4,5)P3 and osmotic regulation.
Examination of molecular graphics representations allowed us to draw tentative conclusions about the environment needed for an hydroxyl group to be phosphorylated by this kinase and to predict successfully that the purified kinase would phosphorylate the 5-hydroxyl of Ins(1,4,6)P3. Expand
Function of Drg1/Rit42 in p53-dependent Mitotic Spindle Checkpoint*
It is shown that the Rit42 protein is a microtubule-associated protein that localizes to the centrosomes and participates in the spindle checkpoint in a p53-dependent manner and plays a role in the regulation of microtubules dynamics and the maintenance of euploidy. Expand