(Aryloxy)methylsilane derivatives as new cholesterol biosynthesis inhibitors: synthesis and hypocholesterolemic activity of a new class of squalene epoxidase inhibitors.
- J. Gotteland, I. Brunel, S. Halazy
- Chemistry, BiologyJournal of Medicinal Chemistry
- 18 August 1995
These new 3-substituted (aryloxy)methylsilane derivatives of benzylamine represent a new class of potent squalene epoxidase inhibitors with promising hypocholesterolemic properties.
Biochemical Changes and Morphological Alterations of Liver and Kidney in Hamsters after Administration of the HMG‐Coenzyme A Reductase Inhibitor, Simvastatin: Prevention and Reversibility by…
- P. Oms, N. Assie, F. Bruniquel, A. Degryse, G. V. Haverbeke, A. Delhon
- Biology, Medicine
- 1 December 1995
It is suggested that the dramatic effect of simvastatin could result from depletion of a non-sterol metabolite of mevalonate in spite of a lack of protective effects of farnesol and geranylgeraniol in the following study.
Pharmacological profile of F 12511, (S)-2',3', 5'-trimethyl-4'-hydroxy-alpha-dodecylthioacetanilide a powerful and systemic acylcoenzyme A: cholesterol acyltransferase inhibitor.
- D. Junquéro, P. Oms, A. Delhon
- Biology, MedicineBiochemical Pharmacology
- 2001
Design and synthesis of new hypocholesterolemic organosilanes with antioxidant properties
- J. Gotteland, A. Delhon, D. Junquéro, P. Oms, S. Halazy
- Chemistry
- 5 March 1996
Effects of the new hypolipidemic agent F 2833 on plasma lipoprotein levels in normal and hyperlipidemic hamsters.
- P. Oms, F. Bruniquel, L. Puech, A. Delhon
- BiologyMethods and Findings in Experimental and Clinical…
- 1 September 1992
F 2833 thus decreased plasma lipids in hamsters that were fed on hyperlipidemic diet to normal values observed in animals fed a standard diet, confirming and extending findings previously obtained in other animal species.
Biochemical changes and morphological alterations of liver and kidney in hamsters after administration of the HMG-coenzyme A reductase inhibitor, simvastatin: prevention and reversibility by…
- P. Oms, N. Assie, F. Bruniquel, A. Degryse, G. van Haverbeke, A. Delhon
- Biology, MedicineActa Pharmacologica et Toxicologica
- 1 September 1994
New derivatives of 2,3,5-trimethyl-4-hydroxy-anilides, their preparation and their therapeutic application
- J. Patoiseau, J. Autin, A. Delhon, P. Oms, D. Junquéro
- Chemistry
- 28 November 1995
1derives of silylmethyl anilines, le2fabrication and their joint use
- S. Halazy, J. Gotteland, A. Delhon, P. Oms, D. Junquéro
- Chemistry
- 8 July 1994
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