• Publications
  • Influence
Global regulatory logic for specification of an embryonic cell lineage
Explanation of a process of development must ultimately be couched in the terms of the genomic regulatory code. Specification of an embryonic cell lineage is driven by a network of interactions amongExpand
  • 323
  • 48
  • PDF
A Genomic Regulatory Network for Development
Development of the body plan is controlled by large networks of regulatory genes. A gene regulatory network that controls the specification of endoderm and mesoderm in the sea urchin embryo isExpand
  • 1,397
  • 42
  • PDF
A regulatory gene network that directs micromere specification in the sea urchin embryo.
Micromeres and their immediate descendants have three known developmental functions in regularly developing sea urchins: immediately after their initial segregation, they are the source of anExpand
  • 239
  • 24
  • PDF
Sea urchin Forkhead gene family: phylogeny and embryonic expression.
Transcription factors of the Forkhead (Fox) family have been identified in many metazoans, and play important roles in diverse biological processes. Here we define the set of fox genes present in theExpand
  • 179
  • 22
  • PDF
Reverse Engineering of Biological Complexity
www.sciencemag.org (this information is current as of January 8, 2009 ): The following resources related to this article are available online atExpand
  • 335
  • 16
  • PDF
Alx1, a member of the Cart1/Alx3/Alx4 subfamily of Paired-class homeodomain proteins, is an essential component of the gene network controlling skeletogenic fate specification in the sea urchin
In the sea urchin embryo, the large micromeres and their progeny function as a critical signaling center and execute a complex morphogenetic program. We have identified a new and essential componentExpand
  • 133
  • 15
A provisional regulatory gene network for specification of endomesoderm in the sea urchin embryo.
We present the current form of a provisional DNA sequence-based regulatory gene network that explains in outline how endomesodermal specification in the sea urchin embryo is controlled. The model ofExpand
  • 317
  • 14
  • PDF
Vasa protein expression is restricted to the small micromeres of the sea urchin, but is inducible in other lineages early in development.
Vasa is a DEAD-box RNA helicase that functions in translational regulation of specific mRNAs. In many animals it is essential for germ line development and may have a more general stem cell role.Expand
  • 98
  • 13
  • PDF
Small Bilaterian Fossils from 40 to 55 Million Years Before the Cambrian
Ten phosphatized specimens of a small (<180 micrometers) animal displaying clear bilaterian features have been recovered from the Doushantuo Formation, China, dating from 40 to 55 million yearsExpand
  • 210
  • 11
Alx1, a member of the Cart1/Alx3/Alx4 subfamily of Paired-class homeodomain proteins, is an essential component of the gene network controlling skeletogenic fate specification in the sea urchin embryo
In the sea urchin embryo, the large micromeres and their progeny function as a critical signaling center and execute a complex morphogenetic program. We have identified a new and essential componentExpand
  • 58
  • 10
  • PDF