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REVIEW: Understanding the construct of impulsivity and its relationship to alcohol use disorders
There are well‐established links between impulsivity and alcohol use in humans and other model organisms; however, the etiological nature of these associations remains unclear. This is likely due, inExpand
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Impairments of Reversal Learning and Response Perseveration after Repeated, Intermittent Cocaine Administrations to Monkeys
The current experiments examined the effects of acute or repeated, intermittent administrations of cocaine on the acquisition and reversal of object discriminations by Vervet monkeys in order to testExpand
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Bidirectional behavioral plasticity of memory reconsolidation depends on amygdalar protein kinase A
Reconsolidation—the stabilization of a memory after retrieval—is hypothesized to be a critical and distinct component of memory processing, the disruption of which results in memory impairment. InExpand
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Acute Hippocampal Brain-Derived Neurotrophic Factor Restores Motivational and Forced Swim Performance After Corticosterone
BACKGROUND Alterations in cellular survival and plasticity are implicated in the neurobiology of depression, based primarily on the characterization of antidepressant efficacy in naïve rodents ratherExpand
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Nicotinic mechanisms involved in the dopamine activating and reinforcing properties of ethanol
Ethanol shares with all major dependence producing drugs the ability to activate brain mesocorticolimbic dopamine neurons, an important part of the brain reward systems. This dopamine activation mayExpand
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Nicotine enhances responding with conditioned reinforcement
RationaleThe mesolimbic dopamine system has been implicated in the primary reinforcing properties of drugs of abuse as well as in enhanced responding with conditioned reinforcement produced byExpand
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The Striatal-Enriched Protein Tyrosine Phosphatase Gates Long-Term Potentiation and Fear Memory in the Lateral Amygdala
BACKGROUND Formation of long-term memories is critically dependent on extracellular-regulated kinase (ERK) signaling. Activation of the ERK pathway by the sequential recruitment of mitogen-activatedExpand
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Repeated Nicotine Exposure Enhances Reward-Related Learning in the Rat
Repeated exposure to addictive drugs causes neuroadaptive changes in cortico-limbic-striatal circuits that may underlie alterations in incentive-motivational processes and reward-related learning.Expand
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A History of Corticosterone Exposure Regulates Fear Extinction and Cortical NR2B, GluR2/3, and BDNF
A history of exposure to stressors may be a predisposing factor for developing posttraumatic stress disorder (PTSD) after trauma. Extinction of conditioned fear appears to be impaired in PTSD, butExpand
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Targeting extinction and reconsolidation mechanisms to combat the impact of drug cues on addiction
Drug addiction is a progressive and compulsive disorder, where recurrent craving and relapse to drug-seeking occur even after long periods of abstinence. A major contributing factor to relapse isExpand
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