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Safety and efficacy of a pentavalent human-bovine (WC3) reassortant rotavirus vaccine.
- T. Vesikari, D. Matson, +25 authors Penny M. Heaton
- The New England journal of medicine
- 5 January 2006
BACKGROUND Rotavirus is a leading cause of childhood gastroenteritis and death worldwide. METHODS We studied healthy infants approximately 6 to 12 weeks old who were randomly assigned to receive… Expand
Addressing parents' concerns: do multiple vaccines overwhelm or weaken the infant's immune system?
Recent surveys found that an increasing number of parents are concerned that infants receive too many vaccines. Implicit in this concern is that the infant's immune system is inadequately developed… Expand
Rotavirus isolate WI61 representing a presumptive new human serotype.
- H. Clark, Y. Hoshino, +4 authors P. Offit
- Biology, Medicine
- Journal of clinical microbiology
- 1 September 1987
A virus (strain WI61) representing a presumptive new human serotype was isolated from an 18-month-old child with gastroenteritis admitted to Children's Hospital of Philadelphia in February 1983. The… Expand
Antigenic mapping of the surface proteins of rhesus rotavirus.
Monoclonal antibodies have been produced and used to map the functional topography of the surface proteins of rhesus rotavirus (RRV) that mediate viral neutralization. Ten monoclonal antibodies… Expand
Communicating science to the public: MMR vaccine and autism.
Media attention and consequent public concerns about vaccine safety followed publication of a small case-series of children who developed autism after receipt of the measles-mumps-rubella (MMR)… Expand
The development of multivalent bovine rotavirus (strain WC3) reassortant vaccine for infants.
Laboratory and clinical studies have been directed toward development of a vaccine against rotavirus gastroenteritis in infants. First, bovine rotavirus strain WC3, which did not induce neutralizing… Expand
Vaccines and autism: a tale of shifting hypotheses.
Although child vaccination rates remain high, some parental concern persists that vaccines might cause autism. Three specific hypotheses have been proposed: (1) the combination measles-mumps-rubella… Expand
Development of a pentavalent rotavirus vaccine against prevalent serotypes of rotavirus gastroenteritis.
- Penny M. Heaton, Michelle G. Goveia, J. Miller, P. Offit, H. Clark
- The Journal of infectious diseases
- 1 September 2005
The strategy of decreasing the morbidity and mortality associated with rotavirus gastroenteritis through vaccination is supported by studies demonstrating that wild-type rotavirus infection protects… Expand
A randomized trial to increase acceptance of childhood vaccines by vaccine-hesitant parents: a pilot study.
- S. E. Williams, R. Rothman, P. Offit, W. Schaffner, M. Sullivan, K. Edwards
- Academic pediatrics
- 1 September 2013
OBJECTIVE A cluster randomized trial was performed to evaluate an educational intervention to improve parental attitudes and vaccine uptake in vaccine-hesitant parents. METHODS Two primary care… Expand
Primary Murine Small Intestinal Epithelial Cells, Maintained in Long-Term Culture, Are Susceptible to Rotavirus Infection
- K. Macartney, D. Baumgart, S. Carding, J. O. Brubaker, P. Offit
- Medicine, Biology
- Journal of Virology
- 15 June 2000
ABSTRACT We describe a method for long-term culture of primary small intestinal epithelial cells (IEC) from suckling mice. IEC were digested from intestinal fragments as small intact units of… Expand