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The clinical course of neuromyelitis optica (Devic’s syndrome)
Objectives: To evaluate the spectrum of neuromyelitis optica (NMO), including characteristics of the index events (optic neuritis [ON]) and myelitis), neuroimaging, CSF, and serologic studies, and to… Expand
Functioning insulinoma--incidence, recurrence, and long-term survival of patients: a 60-year study.
For the 60-year period from 1927 through 1986, we assessed the incidence, recurrence, and long-term survival among all Mayo Clinic patients with histologically confirmed functioning insulinoma. With… Expand
Increased risk of type 2 diabetes in Alzheimer disease.
Alzheimer disease and type 2 diabetes are characterized by increased prevalence with aging, a genetic predisposition, and comparable pathological features in the islet and brain (amyloid derived from… Expand
Prediction of AD with MRI-based hippocampal volume in mild cognitive impairment
Objective: To test the hypothesis that MRI-based measurements of hippocampal volume are related to the risk of future conversion to Alzheimer’s disease (AD) in older patients with a mild cognitive… Expand
Comparison of different MRI brain atrophy rate measures with clinical disease progression in AD
Objective: To correlate different methods of measuring rates of brain atrophy from serial MRI with corresponding clinical change in normal elderly subjects, patients with mild cognitive impairment… Expand
Rates of hippocampal atrophy correlate with change in clinical status in aging and AD
Background: The cognitive continuum in the elderly population can be conceptually divided into those who are functioning normally (control subjects), those with a mild cognitive impairment (MCI), and… Expand
Rate of medial temporal lobe atrophy in typical aging and Alzheimer's disease
Objectives: To determine the annual rates of volumetric change of the hippocampus and temporal horn in cognitively normal elderly control subjects and individually matched patients with AD, and to… Expand
Regional metabolic patterns in mild cognitive impairment and Alzheimer’s disease
Background: Mild cognitive impairment (MCI) is a recently described transitional clinical state between normal aging and AD. Assuming that amnestic MCI patients had pathologic changes corresponding… Expand
Human diabetic endoneurial sorbitol, fructose, and myo‐inositol related to sural nerve morphometry
Fascicles of the sural nerve from each of 20 diabetic patients, mostly with maturity‐onset diabetes, were studied by biochemical and pathological techniques, and results were compared to values found… Expand
Longitudinal assessment of diabetic polyneuropathy using a composite score in the Rochester Diabetic Neuropathy Study cohort
Because there are little satisfactory data on change in severity of diabetic polyneuropathy (DP) over time from study of population-based cohorts of diabetic patients in epidemiologic surveys of DP,… Expand