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Computational Approach for Determining the Spectrum of DNA Damage Induced by Ionizing Radiation
TLDR
To study the characteristics of molecular damage induced by ionizing radiation at the DNA level, Monte Carlo track simulation of energetic electrons and ions in liquid water, a canonical model of B-DNA, and a comprehensive classification of DNA damage in terms of the origin and complexity of damage were used to calculate the frequencies of simple and complex strand breaks. Expand
Computational modelling of low-energy electron-induced DNA damage by early physical and chemical events.
Modelling and calculations are presented as a first step towards mechanistic interpretation and prediction of radiation effects based on the spectrum of initial DNA damage produced by low energyExpand
Low-dose irradiation of nontransformed cells stimulates the selective removal of precancerous cells via intercellular induction of apoptosis.
TLDR
It is reported that irradiation of nontransformed cells with low doses of either high linear energy transfer (LET) alpha-particles or low-LET gamma-rays leads to stimulation of intercellular induction of apoptosis, which may represent a natural anticancer mechanism stimulated by extremelyLow doses of ionizing radiation. Expand
Biological consequences of radiation-induced DNA damage: relevance to radiotherapy.
TLDR
The concepts developed rely in part on the fact that ionising radiation creates significant levels of clustered DNA damage, including complex double-strand breaks (DSB), to kill tumour cells as clustered damage sites are difficult to repair. Expand
Induction and quantification of gamma-H2AX foci following low and high LET-irradiation.
TLDR
Investigating quantitatively the induction and rejoining of DNA double strand breaks (DSB) in V79-4 and xrs-5 Chinese hamster cells and HF19 human fibroblast cells using the phosphorylation of the histone protein H2AX (gamma-H2AX) as an indicator of DSB found variation in the rate of dephosphorylated of induced foci are dependent both on radiation quality and cell characteristics. Expand
Induction and quantification of γ-H2AX foci following low and high LET-irradiation
TLDR
Investigating quantitatively the induction and rejoining of DNA double strand breaks in V79-4 and xrs-5 Chinese hamster cells and HF19 human fibroblast cells using the phosphorylation of the histone protein H2AX (γ-H2AX) as an indicator of DSB found the variation in the rate of dephosphorylated of induced foci are dependent both on radiation quality and cell characteristics. Expand
Dependence of the Yield of DNA Double-Strand Breaks in Chinese Hamster V79-4 Cells on the Photon Energy of Ultrasoft X Rays
TLDR
From the size distribution of small DNA fragments down to 0.48 kbp, it is concluded that DSBs are induced randomly by CK and AlK ultrasoft X rays, which are more efficient per unit dose than γ radiation at inducing DNA D SBs. Expand
Quantitative modelling of DNA damage using Monte Carlo track structure method
TLDR
Data on modelling of DNA damage induced by electrons, protons and alpha-particles to provide an insight into factors which determine the biological effectiveness of radiations of high and low linear energy transfer (LET) are presented. Expand
The dynamics of Ku70/80 and DNA-PKcs at DSBs induced by ionizing radiation is dependent on the complexity of damage
TLDR
The repair of DSBs by NHEJ is highly regulated with pathway choice and kinetics of repair dependent on the chemical complexity of the DSB. Expand
Pathway utilization in response to a site‐specific DNA double‐strand break in fission yeast
TLDR
R roles for Ku70 and Lig4 were identified in suppressing DSB‐induced chromosomal rearrangements associated with gene conversion and these findings are consistent with both competitive and cooperative interactions between components of the HR and NHEJ pathways. Expand
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