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- Publications
- Influence
Multiple forms of plasminogen activator in human breast tumors.
- P. O'Grady, H. R. Lijnen, M. Duffy
- Medicine
- Cancer research
- 1 December 1985
Total plasminogen activator (PA) activity, tissue-type PA (t-PA) activity, urokinase-like PA activity, and immunoreactive t-PA were measured in benign breast tumors (fibroadenomas), primary breast… Expand
Plasminogen activator and cancer.
- M. Duffy, P. O'Grady
- Chemistry, Medicine
- European journal of cancer & clinical oncology
- 1 May 1984
Plasminogen activator is a protease which catalyses the conversion of the inactive plasminogen to the active plasmin. Most transformed cell lines and solid tumors produce elevated levels of… Expand
Comparison of the pharmacokinetics of fosinoprilat with enalaprilat and lisinopril in patients with congestive heart failure and chronic renal insufficiency.
- R. Greenbaum, P. Zucchelli, +7 authors B. Mangold
- Medicine
- British journal of clinical pharmacology
- 2000
AIMS
To compare the serum pharmacokinetics of fosinoprilat with enalaprilat and lisinopril after 1 and 10 days of dosing with fosinopril, enalapril and lisinopril.
METHODS
Patients with congestive… Expand
Pharmacokinetics of Single-Dose Oral Stavudine in Subjects with Renal Impairment and in Subjects Requiring Hemodialysis
- D. Grasela, R. R. Stoltz, +5 authors S. J. Haworth
- Medicine
- Antimicrobial Agents and Chemotherapy
- 1 August 2000
ABSTRACT Two open-label studies assessed the pharmacokinetics of single orally administered doses of 40 mg of stavudine in subjects with renal impairment. In one study (study I), 15 subjects with… Expand
An investigation into the role of oxygen free radical scavengers in preventing polymethylmethacrylate-induced necrosis in an osteoblast cell culture.
- J. Kennedy, P. O'Grady, +7 authors J. Fitzpatrick
- Medicine
- Orthopedics
- 1 May 2000
This study examined the effect of polymethylmethacrylate (PMMA) on osteocytic necrosis and the role of free radical scavengers in minimizing this damage. Bovine osteoblast cells with a characteristic… Expand
Cytophotometric evidence for the transformation of oocytes into nurse cells inDrosophila melanogaster
- R. King, E. Rasch, S. F. Riley, P. O'Grady, P. D. Storto
- Biology, Medicine
- Histochemistry
- 2004
SummaryA small proportion of ovarian chambers from females homozygous for theotu7 (forovariantumor) mutation contain an “oocyte” that in its nuclear morphology resembles a nurse cell. Such… Expand
Tissue-type plasminogen activator, a new prognostic marker in breast cancer.
- M. Duffy, P. O'Grady, D. Devaney, L. O’Siorain, J. Fennelly, H. R. Lijnen
- Medicine
- Cancer research
- 1 March 1988
Plasminogen activator is a protease existing in two forms known as tissue-type and urokinase-type plasminogen activator. In this investigation, patients with breast cancers containing high levels of… Expand
Bath administration of the quinoline antibiotic flumequine to brown trout Salmo trutta and Atlantic salmon S. salar.
- P. O'Grady, M. Moloney, P. Smith
- Biology
- 1988
Administration of flumequine to brown trout S a h o trutta and Atlantic salmon Salmo salar, using bath treatments, resulted in significant serum levels of the antibiotic. Bath concentrations of 50.… Expand
Fosinopril/hydrochlorothiazide: single dose and steady-state pharmacokinetics and pharmacodynamics.
- P. O'Grady, K. Yee, R. Lins, B. Mangold
- Medicine
- British journal of clinical pharmacology
- 1 September 1999
AIMS
Fosinoprilat, the active product of fosinopril, is eliminated by an hepatic pathway in addition to the renal pathway shared by other angiotensin converting enzyme inhibitors (ACEIs). This study… Expand