P. O'Brien

Publications516
h-index104
Citations37,872
Highly Influential Citations1,245
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The clinical course of neuromyelitis optica (Devic’s syndrome)
Objectives: To evaluate the spectrum of neuromyelitis optica (NMO), including characteristics of the index events (optic neuritis [ON]) and myelitis), neuroimaging, CSF, and serologic studies, and to… Expand
  • 1,465
  • 142
Functioning insulinoma--incidence, recurrence, and long-term survival of patients: a 60-year study.
For the 60-year period from 1927 through 1986, we assessed the incidence, recurrence, and long-term survival among all Mayo Clinic patients with histologically confirmed functioning insulinoma. With… Expand
  • 658
  • 45
Prediction of AD with MRI-based hippocampal volume in mild cognitive impairment
Objective: To test the hypothesis that MRI-based measurements of hippocampal volume are related to the risk of future conversion to Alzheimer’s disease (AD) in older patients with a mild cognitive… Expand
  • 1,278
  • 34
Comparison of different MRI brain atrophy rate measures with clinical disease progression in AD
Objective: To correlate different methods of measuring rates of brain atrophy from serial MRI with corresponding clinical change in normal elderly subjects, patients with mild cognitive impairment… Expand
  • 717
  • 33
Rates of hippocampal atrophy correlate with change in clinical status in aging and AD
Background: The cognitive continuum in the elderly population can be conceptually divided into those who are functioning normally (control subjects), those with a mild cognitive impairment (MCI), and… Expand
  • 750
  • 29
Regional metabolic patterns in mild cognitive impairment and Alzheimer’s disease
Background: Mild cognitive impairment (MCI) is a recently described transitional clinical state between normal aging and AD. Assuming that amnestic MCI patients had pathologic changes corresponding… Expand
  • 435
  • 29
Rate of medial temporal lobe atrophy in typical aging and Alzheimer's disease
Objectives: To determine the annual rates of volumetric change of the hippocampus and temporal horn in cognitively normal elderly control subjects and individually matched patients with AD, and to… Expand
  • 556
  • 28
The prevalence by staged severity of various types of diabetic neuropathy, retinopathy, and nephropathy in a population‐based cohort
The magnitude of the health problem from diabetic neuropathies remains inadequately estimated due to the lack of prospective population-based studies employing standardized and validated assessments… Expand
  • 1,231
  • 25
A randomized trial of plasma exchange in acute central nervous system inflammatory demyelinating disease
There are no established treatments for patients with acute, severe neurological deficits caused by multiple sclerosis or other inflammatory demyelinating diseases of the central nervous system who… Expand
  • 710
  • 24
Longitudinal assessment of diabetic polyneuropathy using a composite score in the Rochester Diabetic Neuropathy Study cohort
Because there are little satisfactory data on change in severity of diabetic polyneuropathy (DP) over time from study of population-based cohorts of diabetic patients in epidemiologic surveys of DP,… Expand
  • 312
  • 23