P. O'Brien

Publications330
h-index105
Citations37,309
Highly Influential Citations1,226
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The clinical course of neuromyelitis optica (Devic’s syndrome)
TLDR
Clinical, laboratory, and imaging features generally distinguish neuromyelitis optica from MS, and patients with relapsing optic neuritis and myelitis may have neuromyeliitis opticas rather than MS.
Functioning insulinoma--incidence, recurrence, and long-term survival of patients: a 60-year study.
Increased risk of type 2 diabetes in Alzheimer disease.
TLDR
The hypothesis that patients with Alzheimer disease are more vulnerable to type 2 diabetes and the possibility of linkage between the processes responsible for loss of brain cells and beta-cells in these diseases are supported.
Comparison of different MRI brain atrophy rate measures with clinical disease progression in AD
TLDR
These data support the use of rates of change from serial MRI studies in addition to standard clinical/psychometric measures as surrogate markers of disease progression in AD, and atrophy on MRI was detected more consistently than decline on specific cognitive tests/rating scales.
Rate of medial temporal lobe atrophy in typical aging and Alzheimer's disease
TLDR
A statistically significant yearly decline in hippocampal volume and an increase in temporal horn volume was identified in elderly control subjects who represent typical aging individuals, and these rates were approximately 2.5 times greater in patients with AD than in individually age- and gender-matched control subjects.
Human diabetic endoneurial sorbitol, fructose, and myo‐inositol related to sural nerve morphometry
TLDR
A comparison of scored symptoms and signs and clinical neurophysiological studies against morphometric and teased fiber studies of sural nerve demonstrated that the former three provide sensitive and reliable measures of severity of neuropathy that can be used for controlled clinical trials of diabetic neuropathy.
Regional metabolic patterns in mild cognitive impairment and Alzheimer’s disease
TLDR
Findings suggest that the initial 1H MRS change in the pathologic progression of AD is an increase in MI/Cr, and a decrease in NAA/Cr and an increases in Cho/Cr develop later in the disease course.
DHEA in elderly women and DHEA or testosterone in elderly men.
TLDR
Neither DHEA nor low-dose testosterone replacement in elderly people has physiologically relevant beneficial effects on body composition, physical performance, insulin sensitivity, or quality of life.
Longitudinal assessment of diabetic polyneuropathy using a composite score in the Rochester Diabetic Neuropathy Study cohort
TLDR
Which symptoms, clinical examinations, tests, or combinations of examinations and tests (composite scores) are best used as minimal criteria for the diagnosis of diabetic polyneuropathy and as a quantitative measure of severity of DP are assessed.
A randomized trial of plasma exchange in acute central nervous system inflammatory demyelinating disease
TLDR
Plasma exchange leads to functionally important neurological recovery in an important proportion of severely disabled patients with acute attacks of idiopathic inflammatory demyelinating disease, and was sustained on follow‐up.
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