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AIMS The aim of this study was to assess the tolerability, pharmacokinetics and inhibitory effect on erythrocyte soluble catechol-O-methyltransferase (S-COMT) activity following repeated doses of(More)
BACKGROUND AND OBJECTIVES Opicapone is a novel catechol-O-methyltransferase (COMT) inhibitor. The purpose of this study was to evaluate the tolerability, pharmacokinetics (including the effect of(More)
Catechol-O-methyltransferase (COMT, EC plays a central role in the metabolic inactivation of neurotransmitters and neuroactive xenobiotics possessing a catechol motif.(More)
BACKGROUND AND PURPOSE Catechol-O-methyltransferase (COMT) is an important target in the levodopa treatment of Parkinson's disease; however, the inhibitors available have problems, and not all(More)