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Marine natural products.
This review covers the literature published in 2004 for marine natural products, with 693 citations referring to compounds isolated from marine microorganisms and phytoplankton, green algae, brown algae, red algae, sponges, coelenterates, bryozoans, molluscs, tunicates and echinoderms. Expand
Inhibition of ribosome recruitment induces stress granule formation independently of eukaryotic initiation factor 2alpha phosphorylation.
It is demonstrated that interfering with eIF4A activity, an RNA helicase required for the ribosome recruitment phase of translation initiation, induces SG formation and that this event is not dependent on eIF2alpha phosphorylation. Expand
Aquaculture trials for the production of biologically active metabolites in the New Zealand sponge Mycale hentscheli (Demospongiae: Poecilosclerida)
The results demonstrate that in-sea aquaculture of M. hentscheli is a viable method for supply of mycalamide A, pateamine and peloruside A, and that environmental conditions may be critical for the biosynthesis of pelorusid A. Expand
Insights into the Distinct Mechanisms of Action of Taxane and Non-Taxane Microtubule Stabilizers from Cryo-EM Structures.
The structural analysis illustrates distinct mechanisms of these drugs for stabilizing the MT lattice and is of relevance to the possible use of combinations of MSAs to regulate MT activity and improve therapeutic potential. Expand
Successes and pitfalls of the aquaculture of the sponge Mycale hentscheli
This study documents the development of aquaculture of the sponge Mycale hentscheli over seven years and through three generations of cultivars for the supply and development of an anti-tumour drug from the compound peloruside A. Expand
Structural basis of microtubule stabilization by laulimalide and peloruside A.
Using X-ray crystallography, it is shown that laulimalide and peloruside A bind to a unique non-taxane site on β-tubulin and use their respective macrolide core structures to interact with a second tubulin dimer across protofilaments to stabilize the taxane-site M-loop that establishes lateral tubulin contacts in microtubules. Expand
Peloruside A, a novel antimitotic agent with paclitaxel-like microtubule- stabilizing activity.
Peloruside A is a novel secondary metabolite isolated from a New Zealand marine sponge, Mycale hentscheli, that has potent paclitaxel-like microtubule-stabilizing activity and is cytotoxic atExpand
Spatial and Temporal Variability of Cytotoxic Metabolites in Populations of the New Zealand Sponge Mycale hentscheli
Intraspecific variation in the composition of three cytotoxic secondary metabolites from the New Zealand marine sponge Mycale hentscheli collected at two sites in central New Zealand was quantifiedExpand
Genetic, morphological, and chemical divergence in the sponge genus Latrunculia (Porifera: Demospongiae) from New Zealand
It is concluded that there are at least eight species of Latrunculia in New Zealand waters, not one to four as had been previously thought and the limitations of traditional taxonomic methods based solely on skeletal characters for distinguishing species are emphasised. Expand
Stimulation of mammalian translation initiation factor eIF4A activity by a small molecule inhibitor of eukaryotic translation.
It is suggested that proper control of eIF4A helicase activity is necessary for efficient ribosome binding and the feasibility of selectively targeting DEAD-box RNA helicases with small molecules is demonstrated. Expand