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The complete atomic structure of the large ribosomal subunit at 2.4 A resolution.
The large ribosomal subunit catalyzes peptide bond formation and binds initiation, termination, and elongation factors. We have determined the crystal structure of the large ribosomal subunit fromExpand
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The structural basis of ribosome activity in peptide bond synthesis.
Using the atomic structures of the large ribosomal subunit from Haloarcula marismortui and its complexes with two substrate analogs, we establish that the ribosome is a ribozyme and address theExpand
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The structures of four macrolide antibiotics bound to the large ribosomal subunit.
Crystal structures of the Haloarcula marismortui large ribosomal subunit complexed with the 16-membered macrolide antibiotics carbomycin A, spiramycin, and tylosin and a 15-membered macrolide,Expand
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RNA tertiary interactions in the large ribosomal subunit: The A-minor motif
Analysis of the 2.4-Å resolution crystal structure of the large ribosomal subunit from Haloarcula marismortui reveals the existence of an abundant and ubiquitous structural motif that stabilizes RNAExpand
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Placement of protein and RNA structures into a 5 Å-resolution map of the 50S ribosomal subunit
We have calculated at 5.0 Å resolution an electron-density map of the large 50S ribosomal subunit from the bacterium Haloarcula marismortui by using phases derived from four heavy-atom derivatives,Expand
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Phosphoryl Transfer and Calcium Ion Occlusion in the Calcium Pump
A tight coupling between adenosine triphosphate (ATP) hydrolysis and vectorial ion transport has to be maintained by ATP-consuming ion pumps. We report two crystal structures of Ca2+-boundExpand
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A structural overview of the plasma membrane Na+,K+-ATPase and H+-ATPase ion pumps
Plasma membrane ATPases are primary active transporters of cations that maintain steep concentration gradients. The ion gradients and membrane potentials derived from them form the basis for a rangeExpand
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Crystal structure of the plasma membrane proton pump
A prerequisite for life is the ability to maintain electrochemical imbalances across biomembranes. In all eukaryotes the plasma membrane potential and secondary transport systems are energized by theExpand
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Isotopic Lithium Abundances in Nine Halo Stars
High-resolution echelle spectra of the 6707.8 ? Li I absorption line in spectra of metal-poor halo dwarfs and subgiants are analyzed for the isotopic fractions of 6Li and 7Li. Positive detections ofExpand
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Ribosome-induced changes in elongation factor Tu conformation control GTP hydrolysis
In translation, elongation factor Tu (EF-Tu) molecules deliver aminoacyl-tRNAs to the mRNA-programmed ribosome. The GTPase activity of EF-Tu is triggered by ribosome-induced conformational changes ofExpand
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