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A highly diastereoselective vinylogous Mannich condensation and 1,4-conjugate addition of (Z)-propenyl cuprate in the synthesis of an influenza neuraminidase inhibitor
- D. Barnes, L. Bhagavatula, S. Wittenberger
- Chemistry
- 14 November 2003
Synthesis of methyl-1-(tert-butoxycarbonylamino)-2-vinylcyclopropanecarboxylate via a Hofmann rearrangement utilizing trichloroisocyanuric acid as an oxidant.
- Zackary D Crane, P. Nichols, T. Sammakia, Peter J. Stengel
- ChemistryThe Journal of organic chemistry
- 7 January 2011
A trichloroisocyanuric acid (TCCA) mediated Hofmann rearrangement was utilized to synthesize methyl-1-(tert-butoxycarbonylamino)-2-vinylcyclopropanecarboxylate. A variety of functional groups are…
Preparation of pyrrolidine-based PDE4 inhibitors via enantioselective conjugate addition of alpha-substituted malonates to aromatic nitroalkenes.
- P. Nichols, J. A. Demattei, K. Koch
- Chemistry, BiologyOrganic letters
- 4 March 2006
TLDR
ORGANOYTTRIUM-CATALYZED SEQUENTIAL CYCLIZATION/SILYLATION REACTIONS OF 1,5-DIENES AND 1,6-DIENES
- G. Molander, P. Nichols
- Chemistry
- 1 April 1995
An efficient synthesis of the taxane-derived anticancer agent ABT-271.
- J. A. Demattei, M. Leanna, W. Li, P. Nichols, M. Rasmussen, H. Morton
- ChemistryThe Journal of organic chemistry
- 14 April 2001
TLDR
Total Synthesis of (±)-Epilupinine via an Organoyttrium-Catalyzed Sequential Cyclization/Silylation Reaction
- G. Molander, P. Nichols
- Chemistry
- 23 August 1996
Di(ethylene glycol) vinyl ether: a highly efficient deactivating reagent for olefin metathesis catalysts
- L. Weidong, P. Nichols, N. Smith
- Chemistry
- 11 November 2009
Synthesis of the C-13 side chain precursors of the 9-dihydrotaxane analogue ABT-271.
- M. Leanna, J. A. Demattei, W. Li, P. Nichols, M. Rasmussen, H. Morton
- ChemistryOrganic letters
- 16 November 2000
TLDR
Preparation of Pyrrolidine-Based PDE4 Inhibitors via Enantioselective Conjugate Addition of α-Substituted Malonates to Aromatic Nitroalkenes.
- P. Nichols, J. A. Demattei, K. Koch
- Chemistry
- 15 August 2006
Stereoselective Synthesis of Carbobicyclics via Organoyttrium-Catalyzed Sequential Cyclization/Silylation Reactions
- G. Molander, P. Nichols, B. Noll
- Chemistry
- 13 March 1998
The sequential cyclization/silylation of 1,5-dienes and 1,6-dienes was effected under mild reaction conditions using catalytic quantities of Cp2*YMe·THF. The process provides carbobicyclics in high…
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