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Human Lactoferrin and Peptides Derived from Its N Terminus Are Highly Effective against Infections with Antibiotic-Resistant Bacteria
ABSTRACT Since human lactoferrin (hLF) binds to bacterial products through its highly positively charged N terminus, we investigated which of the two cationic domains is involved in its bactericidalExpand
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Expression of β‐defensin 1 and 2 mRNA by human monocytes, macrophages and dendritic cells
Human β‐defensins are broad‐spectrum antimicrobial peptides known to be produced by epithelial cells. It was recently shown that β‐defensins also display chemotactic activity for dendritic cells (DC)Expand
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Selective stimulation of T helper 2 cytokine responses by the anti‐psoriasis agent monomethylfumarate
Type 2 cytokines are thought to have a protective role in psoriasis vulgaris by dampening the activity of T helper 1 (Th1) lymphocytes. The aim of the present study was to determine the effect ofExpand
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Monomethylfumarate affects polarization of monocyte‐derived dendritic cells resulting in down‐regulated Th1 lymphocyte responses
Psoriasis vulgaris, a type‐1 cytokine‐mediated chronic skin disease, can be treated successfully with fumaric acid esters (FAE). Beneficial effects of this medication coincided with decreasedExpand
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Effects of monomethylfumarate on human granulocytes.
Monomethylfumarate (MMF) is the most active metabolite of the new antipsoriasis drug Fumaderm. Because granulocytes play an important role in the pathophysiology of psoriasis, the effects of thisExpand
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Inducible production of nitric oxide in osteoblast-like cells and in fetal mouse bone explants is associated with suppression of osteoclastic bone resorption.
Nitric oxide (NO) has been suggested to be involved in the regulation of osteoclast activity. Since osteoblasts, through the release of various factors, are the main regulators of osteoclasticExpand
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Candidacidal Activities of Human Lactoferrin Peptides Derived from the N Terminus
ABSTRACT In light of the need for new antifungal agents, the candidacidal activities of human lactoferrin (hLF) and synthetic peptides representing the first, hLF(1-11), and second, hLF(21-31),Expand
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Maggot excretions/secretions are differentially effective against biofilms of Staphylococcus aureus and Pseudomonas aeruginosa.
OBJECTIVES Lucilia sericata maggots are successfully used for treating chronic wounds. As the healing process in these wounds is complicated by bacteria, particularly when residing in biofilms thatExpand
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Rhinovirus increases human beta-defensin-2 and -3 mRNA expression in cultured bronchial epithelial cells.
Human beta-defensins (hBDs) are antimicrobial peptides that play important roles in host defense against infection, inflammation and immunity. Previous studies showed that micro-organisms andExpand
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Pharmacokinetics of oral fumarates in healthy subjects.
AIMS To characterize the pharmacokinetics of fumarates in healthy subjects. METHODS Ten subjects received a single fumarate tablet (containing 120 mg of dimethylfumarate and 95 mg ofExpand
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