P. Newcomb

Publications723
h-index97
Citations44,237
Highly Influential Citations1,158
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Limitations of the odds ratio in gauging the performance of a diagnostic, prognostic, or screening marker.
TLDR
An illustration of the relation between odds ratios and receiver operating characteristic curves shows, for example, that a marker with an odds ratio of as high as 3 is in fact a very poor classification tool.
Lower cancer incidence in Amsterdam-I criteria families without mismatch repair deficiency: familial colorectal cancer type X.
TLDR
Families who fulfill AC-I criteria but who have no evidence of a DNA MMR defect do not share the same cancer incidence as families with HNPCC-Lynch syndrome, and the designation of "familial colorectal cancer type X" is suggested to describe this type of familial aggregation of coloreCTal cancer.
Alcohol, tobacco and breast cancer – collaborative reanalysis of individual data from 53 epidemiological studies, including 58 515 women with breast cancer and 95 067 women without the disease
TLDR
In conclusion, smoking has little or no independent effect on the risk of developing breast cancer; the effect of alcohol on breast cancer needs to be interpreted in the context of its beneficial effects, in moderation, on cardiovascular disease and its harmful effects on cirrhosis.
Physical Activity and Survival after Diagnosis of Invasive Breast Cancer
TLDR
Support is provided for reduced overall mortality and mortality from breast cancer among women who engage in physical activity after breast cancer diagnosis and regardless of a woman’s age, stage of disease, and body mass index.
Global, regional, and national age-sex specific all-cause and cause-specific mortality for 240 causes of death, 1990-2013: A systematic analysis for the Global Burden of Disease Study 2013
Identification of Lynch syndrome among patients with colorectal cancer.
TLDR
Universal tumor MMR testing among CRC probands had a greater sensitivity for the identification of Lynch syndrome compared with multiple alternative strategies, although the increase in the diagnostic yield was modest.
Genome-wide association scan identifies a colorectal cancer susceptibility locus on chromosome 8q24
TLDR
Using a multistage genetic association approach comprising 7,480 affected individuals and 7,779 controls, markers in chromosomal region 8q24 associated with colorectal cancer were identified and this locus has been implicated in prostate cancer.
Socioeconomic Risk Factors for Breast Cancer: Distinguishing Individual- and Community-Level Effects
TLDR
Community SES and urbanicity are apparently not simply proxies for individual SES, and future research should examine why living in such communities itself is associated with greater risk of breast cancer.
Postmenopausal estrogen and progestin use in relation to breast cancer risk.
TLDR
Estrogen-progestin use, both sequential and continuous, appears to be more strongly associated with risk of breast cancer than use of estrogen alone, and use of progestin alone was associated with a doubling of risk.
Association between molecular subtypes of colorectal cancer and patient survival.
TLDR
Based on a large, population-based study, CRC subtypes, defined by proposed etiologic pathways, are associated with marked differences in survival, indicating the clinical importance of studies into the molecular heterogeneity of CRC.
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