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Adjuvant chemotherapy with gemcitabine vs observation in patients undergoing curative-intent resection of pancreatic cancer: a randomized controlled trial.
The results support the use of gemcitabine as adjuvant chemotherapy in resectable carcinoma of the pancreas by significantly delayed the development of recurrent disease after complete resection of pancreatic cancer compared with observation alone.
Extensive genetic polymorphism in the human CYP2B6 gene with impact on expression and function in human liver.
Significant reduced CYP2B6 protein expression and S-mephenytoin N-demethylase activity were found in carriers of the C1459T (R487C) mutation, demonstrating that the extensive interindividual variability of CYP 2B6 expression and function is not only due to regulatory phenomena, but also caused by a common genetic polymorphism.
The genetic determinants of the CYP3A5 polymorphism.
Investigation of the expression of CYP3A5 and its genetic determinants in a panel of 183 Caucasian liver samples reports that a SNP within intron 3 (g.6986G>A) is the primary cause of the CYP4A5 protein polymorphism, and should add to efforts to identify clinically relevant, CYP2A5-specific reactions and to further elucidate traits responsible for variable expression of the entire CYP 3A family.
Extended resections for hilar cholangiocarcinoma.
Extended resections, especially right trisegmentectomies and LTPP, resulted in the highest rate of R0 resection and best represents the principles of surgical oncology and may be regarded as the surgical procedure of choice.
Adjuvant chemotherapy with gemcitabine and long-term outcomes among patients with resected pancreatic cancer: the CONKO-001 randomized trial.
Among patients with macroscopically completely removed pancreatic cancer, the use of adjuvant gemcitabine for 6 months compared with observation alone resulted in increased overall survival as well as disease-free survival, providing strong support for the use in this setting.
Vascular invasion and histopathologic grading determine outcome after liver transplantation for hepatocellular carcinoma in cirrhosis
Tumor diameter and number of nodules in correlation with the histopathologic grading were predictive of a vascular invasion only in HCC larger than 5 cm, which is a safe and effective long‐term treatment for small HCC in cirrhosis.
Sex is a major determinant of CYP3A4 expression in human liver
Sex, in addition to PXR and drug exposure, is a major factor for CYP3A4 expression in humans, thus explaining many of the previous observations of sex‐dependent drug clearance.