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n-3 PUFAs reduce VEGF expression in human colon cancer cells modulating the COX-2/PGE2 induced ERK-1 and -2 and HIF-1alpha induction pathway.
TLDR
Evidence is provided that these n-3 PUFAs are able to inhibit VEGF expression in colon cancer cells and suggest that one possible mechanism involved may be the negative regulation of the COX-2/PGE(2) pathway. Expand
The role of small intestinal bacterial overgrowth in Parkinson's disease
TLDR
The eradication of small intestinal bacterial overgrowth resulted in improvement in motor fluctuations without affecting the pharmacokinetics of levodopa. Expand
Proinflammatory-activated trigeminal satellite cells promote neuronal sensitization: relevance for migraine pathology
TLDR
These findings indicate that satellite cells contribute to migraine-related neurochemical events and are induced to do so by autocrine/paracrine stimuli (such as IL-1β and NO) and, thus, a plurality of targets for therapeutic intervention in migraine. Expand
Intravesical electromotive mitomycin C versus passive transport mitomycin C for high risk superficial bladder cancer: a prospective randomized study.
TLDR
Intravesical electromotive administration increases bladder uptake of MMC, resulting in an improved response rate in cases of high risk superficial bladder cancer. Expand
Expression of iNOS, CD163 and ARG-1 taken as M1 and M2 markers of microglial polarization in human glioblastoma and the surrounding normal parenchyma
TLDR
It was found that CD163 expression was significantly and inversely correlated with mean survival times, with average survival times ranging from 448days in patients having low expression, to 319 in mid, and 353 in patients with high CD163 expressing tumors. Expand
Ghrelin is released from rat hypothalamic explants and stimulates corticotrophin-releasing hormone and arginine-vasopressin.
TLDR
The current data suggest that ghrelin is expressed in the hypothalamus both at RNA and the protein levels, and stimulates the HPA axis in the rat via stimulation of both CRH, and particularly, AVP release fromThe hypothalamus. Expand
CRH inhibits cell growth of human endometrial adenocarcinoma cells via CRH-receptor 1-mediated activation of cAMP-PKA pathway.
TLDR
Experiments with the PKA inhibitor 14-22 amide and forskolin, as well as the measurement of intracellular cAMP, suggested the downstream involvement of cAMP-PKA pathway in CRH-induced inhibition of Ishikawa cell growth. Expand
Intravesical capsaicin versus resiniferatoxin in patients with detrusor hyperreflexia: a prospective randomized study.
TLDR
Intravesical administration of resiniferatoxin is superior to that of Capsaicin in terms of urodynamic results and clinical benefits in spinal cord injured patients and it does not cause the inflammatory side effects associated with capsaicin. Expand
Erythropoietin exerts anti‐apoptotic effects on rat microglial cells in vitro
TLDR
The effects of EPO on primary cultures of rat cortical microglia and astrocytes are investigated and it is found that the cytokine increased microglial cell population size in a concentration‐dependent manner, but EPO did not affect the pro‐inflammatory function ofmicroglial cells. Expand
Electrophysiological and molecular evidence of L‐(Cav1), N‐ (Cav2.2), and R‐ (Cav2.3) type Ca2+ channels in rat cortical astrocytes
TLDR
The novel findings indicate that VGCC expression by corticalastrocytes may be more varied than previously thought, suggesting that these channels may indeed play substantial roles in the regulation of astrocyte Ca2+ influx, which influences neuron‐glia cross‐talk and numerous other calcium‐mediated glial‐cell functions. Expand
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